The Effect of Combined Factor XI Deficiency with von Willebrand Factor Abnormalities on Haemorrhagic Diathesis

Shulamith Tavori; Benjamin Brenner; llana Tatarsky

doi:10.1055/s-0038-1645682

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1990; 63(01): 036-038
DOI: 10.1055/s-0038-1645682

Original Article

Schattauer GmbH Stuttgart

The Effect of Combined Factor XI Deficiency with von Willebrand Factor Abnormalities on Haemorrhagic Diathesis

Shulamith Tavori

The Coagulation Laboratory, Hematology Institute, Rambam Medical Center and Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel

,

Benjamin Brenner

The Coagulation Laboratory, Hematology Institute, Rambam Medical Center and Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel

,

llana Tatarsky

The Coagulation Laboratory, Hematology Institute, Rambam Medical Center and Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel

› Author Affiliations

Abstract

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Summary

To account for the lack of correlation between the level of factor XI (FXI) in deficient patients and haemorrhagic manifestations, we correlated the prevalence of combined FXI and von Willebrand’s factor (vWF) deficiency in 212 FXI-deficient patients. Fifty-four patients had a combined FXI and vWF deficiency: 16 patients had severe and 38 patients had mild FXT deficiency. In a group of 28 patients with comparably mild FXI deficiency, 14 bleeders had significantly lower mean vWF, Ag, ristocetin cofactor and ristocetin induced platelet aggregation than 14 non-bleeders selected on the basis of comparable FXI levels. These findings suggest that the combination of FXI and vWF deficiency is common and may affect the bleeding tendency in mild FXI deficiency.

Keywords

FXI-deficiency - vWF - Combined factor deficiency

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References

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