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Thromb Haemost 1987; 58(01): 387
DOI: 10.1055/s-0038-1644215
Abstracts
RHEOLOGY
Schattauer GmbH Stuttgart

EFFECT OF PIRACETAM ON THE MEAN INTRASPLENIC RED CELL TRANSIT TIME (MST) IN SICKLE CELL DISEASE AND SICKLE CELL THALASSAEMIA

A Ferrant
Departments of Haematology, Nuclear Medicine and Internal Medicine. University of Louvain Medical School, 1200 Brussels, Belgium
,
N Leners
Departments of Haematology, Nuclear Medicine and Internal Medicine. University of Louvain Medical School, 1200 Brussels, Belgium
,
E K Gini
Departments of Haematology, Nuclear Medicine and Internal Medicine. University of Louvain Medical School, 1200 Brussels, Belgium
,
J P Osselaerey
Departments of Haematology, Nuclear Medicine and Internal Medicine. University of Louvain Medical School, 1200 Brussels, Belgium
,
J Sonnet
Departments of Haematology, Nuclear Medicine and Internal Medicine. University of Louvain Medical School, 1200 Brussels, Belgium
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Publikationsdatum:
23. August 2018 (online)

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The effect of Piracetam on the MST has been evaluated in 3 children with homozygous sickle cell disease, and in 1 child and 2 adults with sickle cell β thalassaemia. The MST was measured using 99 Tern labelled autologous red cells before and during treatment with Piracetam (160 mg/kg/d). Tests for in vitro fi1terabi1ity of red cells were performed and an improvement of the in vitro deformabi1ity was observed in all the patients.

A shortening of the MST was also observed :