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Thromb Haemost 1987; 58(01): 385
DOI: 10.1055/s-0038-1644207
Abstracts
DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM
Schattauer GmbH Stuttgart

ANABOLIC STEROID AND INTRAPULMONARY HEPARIN IN THE PREVENTION OF POSTOPERATIVE DEEP VEIN THROMBOSIS

K Zawilska
1   Department of Haematology, Poznań, Poland
,
A Tokarz
2   Department of Surgery, Academy of Medicinie, Poznań, Poland
,
P Psuja
1   Department of Haematology, Poznań, Poland
,
P Szymczak
2   Department of Surgery, Academy of Medicinie, Poznań, Poland
,
S Kawczyński
2   Department of Surgery, Academy of Medicinie, Poznań, Poland
,
M Zozulińska
1   Department of Haematology, Poznań, Poland
,
Z Turowiecka
1   Department of Haematology, Poznań, Poland
,
J Sowier
2   Department of Surgery, Academy of Medicinie, Poznań, Poland
› Author Affiliations
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Publication History

Publication Date:
23 August 2018 (online)

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150 patients over 40 years old undergoing major abdominal surgery were divided into 3 groups:

1/ group I - receiving a single injection of long acting anabolic steroid /nandrolone phenylpropio-nate, 50 mg intramusculary/ a day prior to surgery 2/ gropup II - receiving the same dose of anabolic steroid plus a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery 3/ group III - receiving only a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery.

The deep vein thrombosis /DVT/ was detected using the 125 I-fibrinogen test. The occurence of DVT was:

in group I - 14%

in group II - 4%

in group III - 8%

There were no detectable haemorrhagic complications in patients of group I and III, in 6% of patients of group II a sgliht increase of intraoperative bleeding and/or wound hematoma appeared.

We conclude that prophylaxis of DVT in the postoperative period with the single dose of anabolic steroid and intrapulmonary heparin is an effective, safe and easy to handle procedure.