A concentrate of factor VII obtained by adsorption onto an inorganic adsorbent using
a by-product of routine fractionation as starting material This fraction contains
only small amounts of the other constituents of the prothrombin complex ( PC ) but
it is enriched in proteins C and S. It contains much less VIII CAg than the usual
even activated PC concentrates. The amounts of isoagglutinins anti-A and B have also
been checked. The concentrate of partially versus completely activated factor VII
( by factor Xlla ) has been submitted to animal experiences including those effected
on hemophilic dogs. The concentrate and highly purified factor VII prepared from it
were checked on a serie of chromogenic substrates and inhibitors of proteolytic enzymes
of plasmatic and other origin. The results obtained are compared with those given
by the two most commonly used activated PCCs. The correlation between active F VII
and by-passing activity has been studied. This concentrate might thus be indicated
for the treatment of hemophilia A-patients with inhibitors.
