ORG 10172 CAUSES INCREASED URINARY BLEEDING AFTER TRANSURETHRAL PROSTATECTOMY (TURP)

Standard anticoagulant prophylaxis is rarely used after TURP because it is believed to increase urinary bleeding. Org 10172 prevents experimental thrombosis and causes less bleeding than heparin in animals. We therefore evaluated its influence on urinary blood loss after TURP in a double blind, placebo controlled, study, which examined the effects of three Org 10172 regimens (750 antiXa u/day, 500 u bid, 750 u bid), given subcutaneously. Pilot studies have shown that 750 u bid prevents venous thrombosis (VT) after thoracotomy. At each dose level, 10 patients received Org 10172 and 6 placebo. Because patients had spinal anesthesia, they received their first injection of trial drug after anesthesia was established and immediately before surgery. Bleeding was estimated by measuring urine hemoglobin (Hb) and volume. The three dosage groups all showed trends towards increased postoperative urine bleeding in Org 10172 treated patients, but no apparent increase in blood loss with increasing dose, so they were pooled for analysis:

Hence, Org 10172 in doses which are likely to be needed for VT prevention causes a moderate increase in urine bleeding after TURP.