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Thromb Haemost 1988; 59(02): 284-288
DOI: 10.1055/s-0038-1642772
Original Articles
Schattauer GmbH Stuttgart

Heparin and Fibrinolysis - Comparison of Subcutaneous Administration of Unfractionated and Low Molecular Weight Heparin

E Eriksson
*   The Department of Surgery I, Sahlgrenska sjukhuset, University of Göteborg, Sweden
,
I M Wollter
**   Coagulation Laboratory, Sahlgrenska sjukhuset, University of Güteborg, Sweden
,
B Christenson
**   Coagulation Laboratory, Sahlgrenska sjukhuset, University of Güteborg, Sweden
,
L Stigendal
**   Coagulation Laboratory, Sahlgrenska sjukhuset, University of Güteborg, Sweden
,
B Risberg
*   The Department of Surgery I, Sahlgrenska sjukhuset, University of Göteborg, Sweden
› Author Affiliations
Further Information

Publication History

Received 20 July 1987

Accepted after revision 21 December 1987

Publication Date:
21 May 2018 (online)

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Summary

The effects on the fibrinolytic system after a single s.c. bolus injection (at 9 a.m.) of either 5000 IU conventional heparin or 5000 anti-Xa U of a fractionated low molecular weight heparin (Fragmin, KabiVitrum, Sweden) were investigated in 9 healthy volunteers. The effects were compared to those of an injection of normal saline in 6 volunteers. Samples for biochemical analyses were taken regularily during 6 hours after drug or placebo administration.

In the coagulation system the following parameters were measured: Activated partial thromboplastin time (APTT), anti- Xa activity, thrombin time and fibrinogen. The fibrinolytic system was monitored by analysing: plasminogen, ɑ2-antiplasmin, fibrinogen) degradation products (FDP), euglobulin clot lysis time (ECLT), tissue plasminogen activator (t-PA) activity, t-PA antigen and plasminogen activator inhibitor (PAI) activity. Injection of the 2 drugs was followed by elevations in APTT and anti-Xa activity, and were more pronounced for Fragmin than heparin. The fibrinolytic system exhibited a diurnal variation with decreasing PAI activity and increasing t-PA activity during the day. Volunteers receiving normal saline (placebo) showed a similar pattern. The results were unrelated to heparin.

It is concluded from this study that neither heparin nor Fragmin had any significant effect on the fibrinolytic parameters when measured after a single s.c. bolus injection since the observed variations were within the diurnal range.

Keywords

Unfractionated herpin - Low molecular weight heparin - Fibrinolysis - Tissue plasminogen activator
 

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