Time Dependence of Whole Blood Aggregation in Response to Platelet Activating Factor (PAF)

R R Taylor; J Strophair; M Sturm; R Vandongen; L J Beilin

doi:10.1055/s-0038-1642746

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 59(02): 162-163
DOI: 10.1055/s-0038-1642746

Original Articles

Schattauer GmbH Stuttgart

Time Dependence of Whole Blood Aggregation in Response to Platelet Activating Factor (PAF)

Authors

R R Taylor

The Departments of Medicine and Cardiology, University of Western Australia and Royal Perth Hospital, Western Australia
J Strophair

The Departments of Medicine and Cardiology, University of Western Australia and Royal Perth Hospital, Western Australia
M Sturm

The Departments of Medicine and Cardiology, University of Western Australia and Royal Perth Hospital, Western Australia
R Vandongen

The Departments of Medicine and Cardiology, University of Western Australia and Royal Perth Hospital, Western Australia
L J Beilin

The Departments of Medicine and Cardiology, University of Western Australia and Royal Perth Hospital, Western Australia

Abstract

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Summary

The aggregation/adhesion response to platelet activating factor (PAF) was studied in diluted whole blood by impedance aggregometry. The extent of aggregation varied directly with the interval between blood sampling and aggregation measurement over the first 30 minutes from sampling, then remained stable for the next 60 minutes of observation. This is an effect opposite to that described for aggregation to PAF in platelet rich plasma which, however, cannot be studied soon after sampling. Time dependence of aggregation is important and comparative measurements should be made during the period of stable aggregability.

Keywords

Platelet aggregation - Platelet activating factor

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References

References
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