Thromb Haemost 1995; 74(01): 560-564
DOI: 10.1055/s-0038-1642738
Symposium
Liproproteins and Thrombosis
Schattauer GmbH Stuttgart

LDL-Platelet Interaction Under Oxidative Stress Induces Macrophage Foam Cell Formation

Michael Aviram
Lipid Research Laboratory, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, and the Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

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  • 2 Aviram M, Brook JG. Platelet enhancement of macrophage cholesterol accumulation: a novel mechanism foratherogenesis. In: Molecular Biology of Atherosclerosis. Proceeding of the 57th European Atherosclerosis Society Meeting Haipem MJ. ed John Libbey and Company Limited; London: 1992. 14 67-71
  • 3 Aviram M, Fuhrman B, Brook JG. Platelet-mediated macrophage cholesterol accumulation. In: Atherosclerosis DC. Proceedings of the ninth International Symposium on Atherosclerosis,Rosemont-Chicago IL USA Stein O, Eisenberg S, ad Stein Y. eds. R and L Creative Communications Ltd; Tel-Aviv Israel: 1992. VI Thrombosis and Hemodynamics. 523-526
  • 4 Aviram M. Beyond cholesterol: Modification of lipoproteins and increased atherogenicity. In: Atherosclerosis, Inflammation and Thrombosis. Neri Semeri GG, Gensini GF, Abbate R, Prisco D. eds. Scientific Press-Florence; Italy: 1993: 15-36
  • 5 Aviram M, Brook JG. Platelet activation by plasma lipoproteins. Progress inCardiovascular Disease 1987; 30: 61-72
  • 6 Brook JG, Aviram M. Platelet-lipoprotein Interaction. Seminars in Thromb and Haemosta 1988; 14 (03) 258-265
  • 7 Aviram M. The effect of platelet on macrophage lipoprotein metabolism. Atherosclerosis 1988; 73: 269-271
  • 8 Aviram M. Platelets and arterial wall lesion. In: Current Opinion in Lipidology Atherosclerosis: cell biology and lipoproteins. Coetzee GA, van der Westhuyzen DR. (Eds) 1992; 3 (05) 344-348
  • 9 Sevitt S. Platelets and foam cells in the evolution of atherosclerosis. Histological and immunological studies of human lesions Atherosclerosis 1986; 61: 107-110
  • 10 Ross R. Platelet derived growth factor. Annu Rev Medicine 1987; 38: 71-79
  • 11 Hochgraf E, Levy Y, Aviram M, Brook JG, Cogan U. Lovastatin decreases plasma and platelet cholesterol levels and normalizes elevated platelet fluidity and aggregation in hypercholesterolemic patients. Metabolism 1994; 43: 11-17
  • 12 Kruth HS. Platelet-mediated cholesterol accumulation in cultured aortic smooth muscle cells. Science 1985; 227: 1243-1245
  • 13 Mendelsohn ME, Loscalzo J. Role of platelets in cholesteryl ester formation by U-937 cells. J Clin Invest 1988; 81: 62-68
  • 14 Curtiss LK, Black AA, Takagi Y, Plow EF. New mechanisms for foam cell generation in atherosclerotic lesions. J Clin Invest 1987; 80: 367-373
  • 15 Maor I, Brook JG, Aviram M. Platelet secreted lipoprotein-like particle is taken up by the macrophage scavenger receptor and enhances cellular cholesterol accumulation. Atherosclerosis 1991; 88: 163-174
  • 16 Brown MS, Goldstein JL. Scavenger cell receptor shared. Ann Rev Biochemistry 1983; 52: 223-261
  • 17 Aviram M. Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 1993; 98: 1-9
  • 18 Aviram M, Bierman EL, Chait A. Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells. J Biol Chem 1988; 263: 15416-15422
  • 19 Aviram M, Lund-Katz S, Phillips M, Chait A. The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells. J Biol Chem 1988; 263: 16842-16848
  • 20 Aviram M, Bierman EL, Oram JF. High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages. J Lipid Res 1989; 30: 65-76
  • 21 Suits AG, Chait A, Aviram M, Heinecke JW. Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor dependent foam cell formation. Proc Natl Acad Sci USA 1989; 86: 2713-2717
  • 22 Heinecke JW, Suits AG, Aviram M, Chait A. Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events Arteriosclerosis 1991; 11: 1643-1651
  • 23 Aviram M, Keidar S, Rosenblat M, Brook JG. Reduced uptake of cholesterol esterase modified low density lipoprotein by macrophages. J.Biol Chem 1991; 266: 11567-11574
  • 24 Aviram M, Maor I. Phospholipase A2-modified LDL is taken up at enhanced rate by macrophages. Biochem Biophys Res Commun 1992; 185: 465-472
  • 25 Aviram M, Maor I. Phospholipase D modified low density lipoprotein is taken up by macrophages at increased rate: a possible role for phosphatidic acid. J Clin Invest 1993; 91: 1942-1952
  • 26 Aviram M. Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells. J Biol Chem 1992; 267: 218-225
  • 27 Aviram M. Platelet-modified low-density lipoprotein: studies in normals and in patient with homozygous familial hypercholesterolemia. Clin Biochem 1987; 20: 91-95
  • 28 Aviram M, Fuhrman B, Keidar S, Maor I, Rosenblat M, Dankner G, Brook JG. Platelet-modified low density lipoprotein induces macrophage cholesterol accumulation and platelet activation. J Clin Chem Clin Biochem 1989; 27: 3-12
  • 29 Phillips DR, Arnold K, Innerarity TL. Platelet secretory products inhibt lipoprotein metabolism in macrophages. Nature 1985; 316: 746-748
  • 30 Aviram M. Platelet secretory products enhances LDL receptor activity and inhibit scavenger receptor activity in human monocyte-derived macrophages. Metabolism 1989; 38: 425-430
  • 31 Fuhrman B, Brook JG, Aviram M. Lipid-protein particles secreted from activated platelets reduce macrophage uptake of low density lipoprotein. Atherosclerosis 1991; 89: 163-173
  • 32 Fuhrman B, Brook JG, Aviram M. Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages. Biochim Biophys Acta 1992; 1127: 15-21
  • 33 Fuhiman B, Brook JG, Aviram M. Activated platelet secrete a protein- like factor that stimulates oxidized-LDL receptor activity in macrophages. J Lipid Res 1991; 32: 1113-1123
  • 34 Hussein O, Brook JG, Aviram M. Intraperitoneal injection of platelet secretory products into mice increases macrophage uptake of oxidized low density lipoprotein. Israel: J Med Sci. 1993. 29 8 453-459
  • 35 Aviram M, Fuhrman B, Maor I, Brook GJ. Serotonin increases macrophage uptake of oxidized low density lipoprotein. Eur. J. Clin. Chem. Clin Biochem 1992; 30: 55-61
  • 36 Aviram M. Macrophage-mediated oxidation of LDL and atherosclerosis. In: Lipoprotein oxidation and Atherosclerosis: biological and clinical aspects. Bellomo G, Rice-Evans C. eds. Volume IX Richelieu Press; London, U.K.: 1995. in press
  • 37 Aviram M. Antioxidant-mediated inhibiton of macrophage modification of low density lipoprotein. Life Chemistry Reports 1994; 12: 69-78
  • 38 Hoffman R, Brook GJ, Aviram M. Hypolipidemic drags reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies. In: Mosby Year Book of Endocrinology. Bagdade JD. ed. 1993
  • 39 Aviram M, Dankner G, Brook JG. Platelet secretory products increase LDL oxidation, enhance its uptake by macrophages and reduce its fluidity. Arteriosclerosis 1990; 10: 559-563
  • 40 Keidar S, Kaplan M, Rosenblat M, Brook JG, Aviram M. Apolipoprotein E and lipoprotein lipase reduce macrophage degradation of oxidized VLDL but increase cellular degradation of native VLDL. 1192
  • 41 Aviram M. The contribution of the macrophage receptor for oxidized LDL to its cellualaruptake. Biochim. Biophys. Res Commun 1991; 179: 359-365