Thromb Haemost 1995; 74(01): 058-065
DOI: 10.1055/s-0038-1642653
Symposium
Vascular Wall Cells
Schattauer GmbH Stuttgart

The Vascular Biology of Heart and Lung Preservation for Transplantation

David J Pinsky
Columbia University, College of Physicians and Surgeons, New York, NY, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Young JB, Naftel DC, Bourge RC, Kirklin JK, Clemson BS, Porter CB, Rodeheffer RJ, Kenzora JL. Matching the heart donor and heart transplant recipient, dues for successful expansion of the donor pool: A multivariable, multiinstitutional report. J Heart Lung Transplant 1994; 13: 353-365
  • 2 Kirk AJ B, Colquhoun IW, Dark JH. Lung preservation: a review of current practice and future directions. Ann Thorac Surg 1993 56: 990-1000
  • 3 Belzer F, Southard J. Principles of solid-organ preservation by cold storage. Transplantation. 1988; 45: 673-676
  • 4 Pinsky DJ, Oz MC, Liao H, Morris S, Brett J, Morales A, Karakurum M, Van Lookeren Campagne MM, Nowygrod R, Stem DM. Restoration of the cyclic AMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model. J Clin Invest 1993; 92: 2994-3002
  • 5 Pinsky DJ, Oz MC, Koga S, Taha Z, Broekman MJ, Marcus AJ, Liao H, Naka Y, Brett J, Cannon PJ, Nowygrod R, Malinski T, Stem DM. Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. J Clin Invest 1994; 93: 2291-2297
  • 6 Pinsky DJ, Naka Y, Chowdhury NC, Liao H, Oz MC, Michler RE, Kubaszewski E, Malinski T, Stem DM. The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation. Proc Natl Acad Sci (USA) 1994; 91: 12086-12090
  • 7 Lefer AM, Tsao PS, Lefer DJ, Ma X-L. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. FASEB J 1991; 5: 2029-2034
  • 8 Khuri SF, Flaherty JT, O’Riordan JB, Pitt B, Brawley RK, Donahoo JS, Gott VL. Changes in intramyocardial ST segment voltage and gas tensions with regional myocardial ischemia in the dog. Circulation Res 1975; 37 (04) 455-463
  • 9 Ogawa S, Koga S, Kuwabara K, Morris S, Bilezikian J, Silverstein S, Stem D. Hypoxia-induced increased permeability and lowering of cellular cAMP levels. Am J Physiol 1992; 262C: 546-554
  • 10 Ogawa S, Gerlach H, Esposito C, Pasagian-Macaulay A, Brett J, Stem D. Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. J Clin Invest 1990; 85: 1090-1098
  • 11 Zweier JL, Kuppusamy P, Lutty GA. Measurements of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci (USA) 1988; 85: 4046-4050
  • 12 Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, Wolitzky BA, Norton C, Plocinski J, Benjamin W, Bums DK, Goldstein A, Stem D. Hypoxia-mediated induction of endothelial cell interleukin 1-alpha: an autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 1992; 90: 2333-2339
  • 13 Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan S-D, Anderson M, Sunouchi K, Major J, Hamilton T, Kuwabara K, Rot A, Nowygrod R, Stem D. Hypoxic induction of Interleukin-8 gene expression in human endothelial cells. J Clin Invest 1994; 93: 1564-1570
  • 14 Amould T, Michiels C, Remade J. Increased PMN adherence cm ECs after hypoxia: involvement PAF, CD18/CD11B, and ICAM-1. Am J Physiol 1993; 264 C 1102-1110
  • 15 Yoshida N, Granger D, Anderson D, Rothelein R, Lane C, Kvietys P. Anoxia/reoxygenation-induce neutrophil adherence to cultured endothelial cells. Am J Physiol 1992; 262 H 1891-1898
  • 16 Pinsky DJ, Liao H, Naka Y, Lawson C, MC OZ, Stem DM. Hypoxia- induced Weibel-Palade body release: implications forneutrophil recruitment into ischemic myocardium. Circulation. 1994 90. (4 pt 2): I-K (Abstract)
  • 17 Pinsky DJ, Stem DM. Hypoxia-induced modulation of endothelial cell function, in reperfusion injury and clinical capillary leak syndrome. Zikria B, Oz MC, Carlson RW. eds. Futura Publishing, Connecticut 1994; 31-55
  • 18 Koga S, Morris S, Ogawa S, Bilezikian JP, Chen G, Thompson WJ, Ashikaga T, Brett J, Stem D DM, Pinsky DJ. TNF modulates endothelial permeability and anticoagulant properties by activating phosphodiesterase and decreasing cAMP. Am J Physiol. 1995 in press
  • 19 Lincoln TM. Cornwell TL Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels 1991; 28: 129-137
  • 20 Stamler JS, Loh E, Roddy M-A, Currie KE, Creager MA. Nitric oxide regulates basal and systemic pulmonary vascular resistance in healthy humans. Circulation 1994; 89: 2035-2040
  • 21 Lowenstein C, Snyder S. Nitric oxide, a novel biologic messenger. Cell 1992; 70: 705-707
  • 22 Yang X, Chowdhury N, Cai B, Brett J, Marboe C, Sciacca RR, Michler RE, Cannon PJ. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest 1994; 94: 714-721
  • 23 Worral NK, Lazenby WD, Misko TP, Lin T-S, Rodi CP, Manning PT, Tilton RG, Williamson JR, Ferguson Jr. TB. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med 1995; 181: 63-70
  • 24 Pinsky DJ, Cai B, Yang X, Rodriguez C, Sciacca RR, Cannon PJ. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor b. J Clin Invest 1995; 95: 677-685
  • 25 Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem. J 1992; 281: 419-424
  • 26 Dinarello C. Interleukin-1 and its biologically related cytokines. Adv Immunol 1989; 44: 153-205
  • 27 Baggiolini M, Walz A, Kunkel S. Neutrophil-activating peptide-l/IL-8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-1049
  • 28 Stricter R, Kunkel S, Showell H, Remick D, Phan S, Ward P, Maries R. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF- alpha, LPS, and IL-1 beta. Science 1989; 243: 1467-1469
  • 29 Oz MC, Naka Y, Liao H, Maloney C, Seldomridge A, Michler RE, Smith CR, Rose EA, Pinsky DJ. Coronary sinus interleukin-8 and myoglobin are elevated following human heart transplantation. Circulation 1994; 90 (4 pt 2):I 361
  • 30 Lucchesi BR, Wems SW, Fantone JC. The role of the neutrophil and free radicals in ischemic myocardial injury. J Mol Cell Cardiol 1989; 21: 1241-1251
  • 31 Simpson P, Todd III R, Fantone J, Michelson J, Griffin J, Lucchesi B. Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mol, anti-CDl lb) that inhibits leukocyte adhesion. J Clin Invest 1988; 81: 624-629
  • 32 Naka Y, Stem D DM, Pinsky DJ. Acute Myocardial Infarction: Pathophysiology and Biochemistry of Ischemia, Necrosis, and Reperfusion, in Atherosclerosis and Coronary Artery Disease. Fuster V, Ross R, Topol E. eds. Raven Press; 1995. in press
  • 33 Hall TS, Breda MA, Baumgartner WA, Borkon M, Brawn J, Hutchins GM, Reitz BA. The role ofleukocyte depletion in reducing injury to the lung after hypothermic ischemia. Curr Surg 1987; 44: 137-139
  • 34 Pillai R, Bando K, Schueler S, Zebly M, Reitz BA, Baumgartner WA. Leukocyte depletion results in excellent heart-lung function after 12 hours of storage. Ann Thorac Surg 1990; 50: 211-14
  • 35 Adkins WK, Taylor AE. Role of xanthine oxidase and neutrophils in ischemia-reperfusion injury in rabbit lung. J Appl Physiol 1990; 69: 2012-2018
  • 36 Kloner RA, Ganote CE, Jennings RB. The “no-reflow” phenomenon after temporary coronary occlusion in the dog. J Clin Invest 1974; 54: 1496-1508
  • 37 Jerome SN, Dore M, Paulson JC, Smith CW, Korthuis RJ. P-selectin and ICAM-1 -dependent adherence reactions: role in the genesis of postischemic no-reflow. Am J Physiol 1994; 266H: 1316-1321
  • 38 Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin deficient mice. Cell 1993; 74: 541-554
  • 39 Bonfanti R, Furie BC, Furie B, Wagner DD. PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 1989; 73 (05) 1109-1112
  • 40 Naka Y, Chowdhury NC, Michler RE, Liao H, Stem DM, Pinsky DJ. Deleterious effects of P-selectin-dependent neutrophil recruitment on graft survival and function in an orthotopic rat lung transplant model. Circulation 1994; 90 (4 pt 2):I 937 (Abstract)
  • 41 Boxer L, Allen J, Baehner R, Amick V. Diminished polymorphonuclear adherence. J. Clin. Invest 1980; 66: 268-274
  • 42 Malinski T, Taha Z. Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor. Nature 1992; 358: 676-678
  • 43 Oz MC, Pinsky DJ, Koga S, Liao H, Marboe CC, Han D, Kline R, Jeevanandam V, Williams M, Morales A, Popilskis S, Nowygrod R, Stem DM, Rose EA, Michler RE. Novel preservation solution permits 24-hour preservation in rat and baboon cardiac transplant models. Circulation 1993; 88 (5 pt. 2) 291-297
  • 44 Weyrich AS, Ma X-L, Lefer DJ, Albertine KH, Lefer AM. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 1993; 91: 2629-2629
  • 45 Chowdhury NC, Naka Y, Pinsky DJ, Yano OJ, Smith CR, Rose EA, Stem DM, Michler RE, Oz MC. Novel technique of orthotopic lung transplantation in rats in which survival and hemodynamic assessment can be measured independent of the native lung. Surgical Forum 1994; 45: 268-270
  • 46 Naka Y, Chowdhury NC, Liao H, Michler RE, Stem DM, Pinsky DJ. Elevation of intracellular cAMP by a phosphodiesterase inhibitor or cAMP analogs improves vascular function in orthotopic rat lung transplants. Circulation 1994; 90 (4 pt 2):I 804 (Abstract)
  • 47 Miyamoto Y, Lajos TZ, Bhayana JN, Bergsland J, Celik CF. Beneficial effects of prostaglandin El on autoperfused heart-lung preservation. J Heart Transplant 1988; 7: 135-139
  • 48 Lawson CA, Smerling AM, Naka Y, Burkhoff D, Dickstein M, Stem DM, Pinsky DJ. Inhalation of cGMP analogs selectively reduces pulmonary vascular resistance in a porcine model of pulmonary hypertension. Am J Physiol. in press 1995
  • 49 Naka Y, Chowdhury NC, Liao H, Roy DK, Oz MC, Michler RE, Pinsky DJ. Enhanced preservation of orthotopically transplanted rat lungs by nitroglycerin butnot hydralazine: requirement for graft vascular homeostasis beyond harvest vasodilation. Circulation Research. in press 1995
  • 50 Naka Y, Chowdhury NC, Oz MC, Smith CR, Yano OJ, Michler RE, Stem DM, Pinsky DJ. Nitroglycerin maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model. J Thoracic and Cardiovasc Surg 1995; 109: 206-211