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Thromb Haemost 1995; 74(01): 007-017
DOI: 10.1055/s-0038-1642646
Special Colloquium
Schattauer GmbH Stuttgart

The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”

Samuel I Rapaport
Department of Medicine, University of California, San Diego, CA, USA
,
L Vijaya Mohan Rao
Department of Biochemistry, The University of Texas Health Center, Tyler, TX, USA
› Author Affiliations
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Publication History

Publication Date:
09 July 2018 (online)

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  • References

  • 1 Morawitz P. Die chemie der Blutgerinmmg. Ergeb Physiol 1905; 4: 307-314
    CrossrefPubMedGoogle Scholar
  • 2 Morawitz P. Translated by Hartmann RC, Guenther PF. The Chemistry of Blood Coagulation. C.C. Thomas Springfield; MA: 1958: 194
    Google Scholar
  • 3 Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: Implications for disorders of hemostasis and thrombosis. Am J Path 1989; 134: 1087-1097
    PubMedGoogle Scholar
  • 4 Fleck RA, Rao LVM, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res 1990; 59: 421-437
    CrossrefPubMedGoogle Scholar
  • 5 Eddleston M, De La Torre JC, Oldstone MB, Loskutoff DJ, Edgington TS, Mackman N. Astrocytes are the primary source of tissue factor in the murine central nervous system. J Clin Invest 1993; 92: 349-358
    CrossrefPubMedGoogle Scholar
  • 6 Ratnoff OD, Colopy JE. A familial hemorrhagic trait associated with deficiency of a clot-promoting factor of plasma. J Clin Invest 1955; 34: 602-613
    CrossrefPubMedGoogle Scholar
  • 7 Waaler BA. Simultaneous contribution to the formation of thrombin by the intrinsic and extrinsic blood clotting systems. Scand J Clin Lab Invest 1957; 9: 322-330
    CrossrefPubMedGoogle Scholar
  • 8 Quick AJ, Stanley-Brown M, Bancroft FW. A study of the coagulation defect in hemophilia and jaundice. Am J Med Sci 1935; 190: 501-511
    CrossrefPubMedGoogle Scholar
  • 9 Hicks ND. A coagulation disorder due to a factor VII-like defect. Med J Aust 1955; 42: 331-335
    PubMedGoogle Scholar
  • 10 Ackroyd JF. The function of factor VII. Br J Haematol 1956; 2: 397-411
    CrossrefPubMedGoogle Scholar
  • 11 Telfer TP, Denson KW, Wright DR. A “new” coagulation defect. Br J Haematol 1956; 2: 308-316
    CrossrefPubMedGoogle Scholar
  • 12 Hougie C, Barrow EM, Graham JB. Stuart clotting defect. I. Segregation of an hereditary state from the heterogeneous group heretofore called “stable factor” (SPCA, proconvertin, factor VII) deficiency. J Clin Invest 1957; 36: 485-496
    CrossrefPubMedGoogle Scholar
  • 13 MacFarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 1964; 202: 498-499
    CrossrefPubMedGoogle Scholar
  • 14 Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310-1312
    CrossrefPubMedGoogle Scholar
  • 15 Hougie C, Denson KW, Biggs R. A study of the reaction product of factor VIII and factor DC. Thromb Diath Haemorrh 1967; 18: 211-222
    PubMedGoogle Scholar
  • 16 Hemker HC, Kahn MJ. Reaction sequence of blood coagulation. Nature 1967; 215: 1201-1202
    CrossrefPubMedGoogle Scholar
  • 17 Barton PG. Sequence theories of blood coagulation re-evaluated with reference to lipid-protein interactions. Nature 1967; 215: 1508-1509
    CrossrefPubMedGoogle Scholar
  • 18 Østerud B, Rapaport SI. Synthesis of intrinsic factor X activator. Inhibition of the function of formed activator by antibodies to factor VIII and factor IX. Biochem 1970; 9: 1854-1861
    CrossrefPubMedGoogle Scholar
  • 19 Ratnoff OD, Margolius A. Hageman factor and Hageman trait. In: Hemophilia and hemophiliod diseases. Brinkhous KM. ed. Univ. North Carolina Press; Chapel Hill: 1957: 12
  • 20 Rosenthal RL, Dreskin OH, Rosenthal N. Plasma thromboplastin antecedent (PTA) deficiency: clinical, coagulation, therapeutic and hereditary aspects of a new hemophilia-like disease. Blood 1955; 10: 120-131
    PubMedGoogle Scholar
  • 21 Rapaport SI, Proctor RR, Patch MJ, Yettra M. The mode of inheritance of PTA deficiency: evidence for the existence of major PTA deficiency and minor deficiency. Blood 1961; 18: 149-165
    CrossrefPubMedGoogle Scholar
  • 22 Biggs R, Nossel HL. Tissue extract and the contact reaction of blood coagulation. Thromb Diath Haemorrh 1961; 6: 1-14
    PubMedGoogle Scholar
  • 23 Josso F, Prou-Wartelle O. Interaction of tissue factor and factor VII at the earliest phase of coagulation. Thromb Diath Haemorrh 1965; (Suppl. 17) 35-44
    PubMedGoogle Scholar
  • 24 Rapaport SI, Hjort PF, Patch MJ, Jeremic M. Consumption of serum factors and prothrombin during intravascular clotting in rabbits. Scand J Haematol 1966; 3: 59-75
    PubMedGoogle Scholar
  • 25 Østerad B, Rapaport SI. Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation. Proc Natl Acad Sci U S A 1977; 74: 5260-5264
    CrossrefPubMedGoogle Scholar
  • 26 Almus FE, Rao LVM, Rapaport SI. Functional properties of factor VIIa/tissue factor formed with purified tissue factor and with tissue factor expressed on cultured endothelial cells. Thromb Haemostas 1989; 62: 1067-1073
    PubMedGoogle Scholar
  • 27 Komiyama Y, Pedersen AH, Kisiel W. Proteolytic activation of human factors IX and X by recombinant human factor VIIa: Effects of calcium, phospholipids, and tissue factor. Biochem 1990; 29: 9418-9425
    CrossrefPubMedGoogle Scholar
  • 28 Bom VJJ, van Hinsbergh VWM, Reinalda-Poot HH, Mohanlal RW, Bertina RM. Extrinsic activation of human coagulation factors IX and X on the endothelial surface. Thromb Haemostas 1991; 66: 283-291
    PubMedGoogle Scholar
  • 29 Rao LVM, Robinson T, Hoang AD. Factor VIIa/tissue factor-catalyzed activation of factors IX and X on a cell surface and in suspension: A kinetic study. Thromb Haemostas 1992; 67: 654-659
    PubMedGoogle Scholar
  • 30 Marlar RA, Kleiss AJ, Griffin JH. An alternative extrinsic pathway of human blood coagulation. Blood 1982; 60: 1353-1358
    PubMedGoogle Scholar
  • 31 Stem D, Nawroth P, Handley D, Kisiel W. An endothelial cell-dependent pathway of coagulation. Proc Natl Acad Sci U S A 1985; 82: 2523-2527
    CrossrefPubMedGoogle Scholar
  • 32 Lawson JH, Kalafatis M, Stram S, Mann KG. A model for the tissue factor pathway to thrombin. J Biol Chem 1994; 269: 23357-23366
    PubMedGoogle Scholar
  • 33 Schmaier AH, Silverberg M, Kaplan AP, Colman RW. Contact activation and its abnormalities. In: Haemostasis and Thrombosis: Basic Principles and Clinical Practice. Colman RW, Hirsh J, Marder VJ, Salzman EW. eds. J.B. Lippincott; Philadelphia, PA: 1987: 18-38
  • 34 Roberts HR, Lefkowitz JB. Inherited disorders of prothrombin conversion. In: Haemostasis and Thrombosis: Basic Principles and Clinical Practice. Colman RW, Hirsh J, Marder VJ, Salzman EW. eds. J.B. Lippincott; Philadelphia, PA: 1994: 200-218
  • 35 Rapaport SI, Rao LVM. Initiation and regulation of tissue factor-dependent blood coagulation. Arterioscler Thromb 1992; 12: 1111-1121
    CrossrefPubMedGoogle Scholar
  • 36 Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochem 1991; 30: 10363-10370
    CrossrefPubMedGoogle Scholar
  • 37 Nemerson Y. The tissue factor pathway of blood coagulation. Semin Hematol 1992; 29: 170-176
    PubMedGoogle Scholar
  • 38 Lindahl AK, Sandset PM, Abildgaard U. The present status of tissue factor pathway inhibitor. Blood Coagul Fibrinolysis 1992; 3: 439-449
    CrossrefPubMedGoogle Scholar
  • 39 Broze GJ. The role of tissue factor path way inhibitor in a revised coagulation cascade. Semin Hematol 1992; 29: 159-169
    PubMedGoogle Scholar
  • 40 Carson SD, Brozna JP. The role of tissue factor in the production of thrombin. Blood Coagul Fibrinolysis 1993; 4: 281-292
    CrossrefPubMedGoogle Scholar
  • 41 Ruf W, Edgington TS. Structural biology of tissue factor, the initiator of thrombogensis in vivo. FASEB J 1994; 8: 385-390
    CrossrefPubMedGoogle Scholar
  • 42 Zur M, Radcliffe RD, Oberdick J, Nemerson Y. The Dual role of factor VII in blood coagulation. Initiation and inhibition of a proteolytic system by zymogen. J Biol Chem 1982; 257: 5623-5631
    PubMedGoogle Scholar
  • 43 Rao LVM, Rapaport SI, Bajaj SP. Activation of human factor VII in the initiation of tissue factor-dependent coagulation. Blood 1986; 68: 685-691
    PubMedGoogle Scholar
  • 44 Rao LVM, Rapaport SI. Activation of factor VII bound to tissue factor: A key early step in the tissue factor pathway of blood coagulation. Proc Natl Acad Sci U S A 1988; 85: 6687-6691
    CrossrefPubMedGoogle Scholar
  • 45 Williams EB, Krishnaswamy S, Mann KG. Zymogen/enzyme discrimination using peptide chloromethyl ketones. J Biol Chem 1989; 264: 7536-7545
    PubMedGoogle Scholar
  • 46 Wildgoose P, Berkner KL, Kisiel W. Synthesis, purification, and characterization of an Argl52—Glu site-directed mutant of recombinant human blood clotting factor VII. Biochem J 1990; 29: 3413-3420
    CrossrefPubMedGoogle Scholar
  • 47 Nemerson Y, Repke D. Tissue factor accelerates the activation of coagulation factor VII: the role of a bifunctional coagulation cofactor. Thromb Res 1985; 40: 351
    CrossrefPubMedGoogle Scholar
  • 48 Bauer KA, Kass BL, Ten Cate H, Hawiger JJ, Rosenberg RD. Factor IX is activated in vivo by the tissue factor mechanism. Blood 1990; 76: 731-736
    PubMedGoogle Scholar
  • 49 Bauer KA, Mannucci PM, Gringeri A, Tradati F, Barzegar S, Kass BL, Ten Cate H, Kestin AS, Brettler DB, Rosenberg RD. Factor IXa-factor VIIIa-cell surface complex does not contribute to the basal activation of the coagulation mechanism in vivo. Blood 1992; 79: 2039-2047
    PubMedGoogle Scholar
  • 50 Miller BC, Hultin MB, Jesty J. Altered factor VII activity in hemophilia. Blood 1985; 65: 845-849
    PubMedGoogle Scholar
  • 51 Wildgoose P, Nemerson Y, Hansen LL, Nielsen FE, Glazer S, Hedner U. Measurement of basal levels of factor VIIa in hemophilia A and B patients. Blood 1992; 80: 25-28
    PubMedGoogle Scholar
  • 52 Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993; 81: 734-744
    PubMedGoogle Scholar
  • 53 Tsuji A, Torres-Rosado A, Arai T, Le Beau MM, Lemons RS, Chou S-H, Kurachi K. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. J Biol Chem 1991; 266: 16948-16953
    PubMedGoogle Scholar
  • 54 Kazama Y, Hamamoto T, Foster DC, Kisiel W. Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin. J Biol Chem 1995; 270: 66-72
    CrossrefPubMedGoogle Scholar
  • 55 Nakagaki T, Foster DC, Berkner KL, Kisiel W. Initiation of the extrinsic pathway of blood coagulation: Evidence for the tissue factor dependent autoactivation of human coagulation factor VII. Biochem 1991; 30: 10819-10824
    CrossrefPubMedGoogle Scholar
  • 56 Yamamoto M, Nakagaki T, Kisiel W. Tissue factor dependent autoactivation of human blood coagulation factor VII. J Biol Chem 1992; 267: 19089-19094
    PubMedGoogle Scholar
  • 57 Neuenschwander PF, Morrissey JH. Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity. J Biol Chem 1992; 267: 14477-14482
    PubMedGoogle Scholar
  • 58 Neuenschwander PF, Fiore MM, Morrissey JH. Factor VII autoactivation proceeds via interaction of distinct protease-cofactor and zymogen-cofactor complexes. J Biol Chem 1993; 268: 21489-21492
    PubMedGoogle Scholar
  • 59 Rao LVM, Williams T, Rapaport SI. The inability to obtain evidence for an important role for autoactivation of factor VII bound to tissue factor in tissue factor dependent blood coagulation. Thromb Haemostas. 1995: 73 In press. (Abstract)
    PubMedGoogle Scholar
  • 60 Higashi S, Nishimura H, Fujii S, Takada K, Iwanaga S. Tissue factor potentiates the factor VIIa-catalyzed hydrolysis of an ester substrate. J Biol Chem 1992; 267 (25) 17990-17996
    PubMedGoogle Scholar
  • 61 Pedersen AH, Nordfang O, Norris F, Wiberg FC, Christensen PM, Moeller KB, Meidahl-Pedersen J, Beck TC, Norris K, Hedner U, Kisiel W. Recombinant human extrinsic pathway inhibitor: Production, isolation, and characterization of its inhibitory activity on tissue factor-initiated coagulation reactions. J Biol Chem 1990; 265: 16766-16793
    PubMedGoogle Scholar
  • 62 Lawson JH, Butenas S, Mann KG. The evaluation of complex-dependent alterations in human factor VIIa. J Biol Chem 1992; 267: 4834-4843
    CrossrefPubMedGoogle Scholar
  • 63 Ruf W, Miles DJ, Rehemtulla A, Edgington TS. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease. J Biol Chem 1992; 267: 6375-6381
    PubMedGoogle Scholar
  • 64 Ruf W, Schullek JR, Stone MJ, Edgington TS. Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochem 1994; 33: 1565-1572
    CrossrefPubMedGoogle Scholar
  • 65 Ruf W. Factor VIIa residue Arg290 is required for efficient activation of the macromolecular substrate factor X. Biochem 1994; 33: 11631-11636
    CrossrefPubMedGoogle Scholar
  • 66 Chargaff E. Remarks on the role of lipids in blood coagulation. Arch Sci Physiol 1948; 2: 269-271
    PubMedGoogle Scholar
  • 67 Hvatum M, Prydz H. Studies on tissue thromboplastin - Its splitting into two separable parts. Thromb Diath Haemorrh 1969; 21: 217-222
    PubMedGoogle Scholar
  • 68 Ruf W, Rehemtulla A, Morrissey JH, Edgington TS. Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem 1991; 266: 2158-2166
    PubMedGoogle Scholar
  • 69 Bach R, Gentry R, Nemerson Y. Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine. Biochem 1986; 25: 4007-4020
    CrossrefPubMedGoogle Scholar
  • 70 Le DT, Rapaport SI, Rao LVM. Studies of the mechanism for enhanced cell surface factor VIIa/tissue factor activation of factor X in fibroblast monolayers after their exposure to N-ethylmalemide. Thromb Haemostas 1994; 72: 848-855
    PubMedGoogle Scholar
  • 71 Forman SD, Nemerson Y. Membrane-dependent coagulation reaction is independent of the concentration of phospholipid-bound substrate: fluid phase factor X regulates the extrinsic system. Proc Natl Acad Sci USA 1986; 83: 4675-4679
    CrossrefPubMedGoogle Scholar
  • 72 Krishnaswamy S, Field KA, Edgington TS, Morrissey JH, Mann KG. Role of the membrane surface in the activation of human coagulation factor X. J Biol Chem 1992; 267: 26110-26120
    PubMedGoogle Scholar
  • 73 Fiore M, Neuenschwander PF, Morrissey JH. The biochemical basis for the apparent defect of soluble mutant tissue factor in enhancing the proteolytic activities of factor VIIa. J Biol Chem 1994; 269: 143-149
    PubMedGoogle Scholar
  • 74 Rezaie AR, Neuenschwander PF, Morrissey JH, Esmon CT. Analysis of the functions of the first epidermal growth factor-like domain of factor X. J Biol Chem 1993; 268: 8176-8180
    PubMedGoogle Scholar
  • 75 Le DT, Rapaport SI, Rao LVM. Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol Chem 1992; 267: 15447-15454
    PubMedGoogle Scholar
  • 76 Andree HAM, Contino PB, Repke D, Gentry R, Nemerson Y. Transport rate limited catalysis on macroscopic surfaces: The activation of factor X in a continuous flow enzyme reactor. Biochem 1994; 33: 4368-4374
    CrossrefPubMedGoogle Scholar
  • 77 Rao LVM, Tait JF, Hoang AD. Binding of annexin V to a human ovarian carcinoma cell line (OC-2008). Contrasting effects on cell surface factor VIIa/tissue factor activity and prothrombinase activity. Thromb Res 1992; 67: 517-531
    CrossrefPubMedGoogle Scholar
  • 78 Neuenschwander P, Morrissey JH. Roles of the membrane-interactive regions of factor VIIa and tissue factor. J Biol Chem 1994; 269: 8007-8013
    PubMedGoogle Scholar
  • 79 Marciniak E. Factor-Xa inactivation by antithrombin III: evidence for biological stabilization of factor Xa by factor V-phospholipid complex. Br J Haematol 1973; 24: 391-400
    CrossrefPubMedGoogle Scholar
  • 80 Nesheim ME, Canfield WM, Kisiel W, Mann KG. Studies of the capacity of factor Xa to protect factor Va from inactivation of activated protein C. J Biol Chem 1982; 257: 1271-1281
    PubMedGoogle Scholar
  • 81 Rapaport SI. Inhibition of factor VIIa/tissue factor-induced blood coagulation: with particular emphasis upon a factor Xa-dependent inhibitory mechanism. Blood 1989; 73: 359-365
    PubMedGoogle Scholar
  • 82 Broze Jr GJ, Girard TJ, Novotny WF. Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochem 1990; 29: 7539-7545
    CrossrefPubMedGoogle Scholar
  • 83 Shigematsu Y, Miyata T, Higashi S, Miki T, Sadler JE, Iwanaga S. Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa. J Biol Chem 1992; 267: 21329-21337
    PubMedGoogle Scholar
  • 84 Lawson JH, Butenas S, Ribarik N, Mann KG. Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. J Biol Chem 1993; 268: 767-770
    PubMedGoogle Scholar
  • 85 Rao LVM, Rapaport SI, Hoang AD. Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood 1993; 81: 2600-2607
    PubMedGoogle Scholar
  • 86 Broze Jr GJ, Likert K, Higuchi D. Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor. Blood 1993; 82: 1679-1680
    PubMedGoogle Scholar
  • 87 Sprecher CA, Kisiel W, Mathewes S, Foster DC. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. Proc Natl Acad Sci USA 1994; 91: 3353-3357
    CrossrefPubMedGoogle Scholar
  • 88 Key NS, Nelsestuen GL, Slungaard A. Platelet factor 4 (PF4) binds to the gamma-carboxy glutamic acid (GLA) domain of factor X and impairs tissue factor (TF)-mediated coagulation: Possible role as physiologic anticoagulant. Blood 1994; 84: 532 (Abstract)
    PubMedGoogle Scholar
  • 89 Rapaport SI. The extrinsic pathway inhibitor: a regulator of tissue factor-dependent blood coagulation. Thromb Haemostas 1991; 66: 6-15
    PubMedGoogle Scholar
  • 90 Broze Jr GJ, Warren LA, Novotny WF, Higuchi DA, Girard JJ, Miletich JP. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood 1988; 71: 335-343
    PubMedGoogle Scholar
  • 91 Wam-Cramer BJ, Rao LVM, Maki SL, Rapaport SI. Modifications of extrinsic pathway inhibitor (EPI) and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: Evidence for a two-step model of inhibition. Thromb Haemostas 1988; 60: 453-456
    PubMedGoogle Scholar
  • 92 Callander NS, Rao LVM, Nordfang O, Sandset PM, Wam-Cramer B, Rapaport SI. Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa. J Biol Chem 1992; 267: 876-882
    PubMedGoogle Scholar
  • 93 Nordfang O, Bjoum SE, Valentin S, Nielsen LS, Wildgoose P, Beck TC, Hedner U. The C-terminus of tissue factor pathway inhibitor (TFPI) is essential to its anticoagulant activity. Biochem 1991; 30: 10371-10376
    CrossrefPubMedGoogle Scholar
  • 94 Wesselschmidt R, Likert K, Girard T, Wun TC, Broze Jr GJ. Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa. Blood 1992; 79: 2004-2010
    PubMedGoogle Scholar
  • 95 Lindhout T, Willems G, Blezer R, Hemker HC. Kinetics of the inhibition of human factor Xa by full-length and truncated recombinant tissue factor pathway inhibitor. Biochem J 1994; 297: 131-136
    CrossrefPubMedGoogle Scholar
  • 96 Wesselschmidt R, Likert K, Huang Z, MacPhail L, Broze Jr GJ. Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin. Blood Coagul Fibrinolysis 1993; 4: 661-669
    CrossrefPubMedGoogle Scholar
  • 97 Hamamoto T, Yamamoto M, Nordfang O, Petersen JGL, Foster DC, Kisiel W. Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces. J Biol Chem 1993; 268: 8704-8710
    PubMedGoogle Scholar
  • 98 Valentin S, Nordfang O, Lindhout T. Comparison of different TFPI forms during flow with respect to inhibitory properties and stability of TFPI/FXa/FVIIa/TF complex. Haemostasis 1994; 24: 254a
    PubMedGoogle Scholar
  • 99 Broze Jr GJ, Lange GW, Duffin KL, Mac Phail L. Heterogeneity of plasma tissue factor pathway inhibitor. Blood Coagul Fibrinolysis 1994; 5: 551-559
    PubMedGoogle Scholar
  • 100 Sandset PM, Abildgaard U, Larsen ML. Heparin induces release of extrinsic coagulation pathway inhibitor (EPI). Thromb Res 1988; 50: 803-813
    CrossrefPubMedGoogle Scholar
  • 101 Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze Jr GJ. Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood 1991; 78: 387-393
    PubMedGoogle Scholar
  • 102 Palmier MO, Hall LJ, Reisch CM, Baldwin MK, Wilson AGE, Wun T-Z. Clearance of recombinant tissue factor pathway inhibitor (TFPI) in rabbits. Thromb Haemostas 1992; 68: 33-36
    PubMedGoogle Scholar
  • 103 Bregengard C, Nordfang O, Ostergaard P, Petersen JG, Meyn G, Diness V, Svendsen O, Hedner U. Pharmacokinetics of full length and two-domain tissue factor pathway inhibitor in combination with heparin in rabbits. Thromb Haemostas 1993; 70: 454-457
    PubMedGoogle Scholar
  • 104 Bauer KA, Kass BL, Ten Cate H, Bednarek MA, Hawiger JJ, Rosenberg RD. Detection of factor X activation in humans. Blood 1989; 74: 2007-2015
    PubMedGoogle Scholar
  • 105 Warshawsky I, Broze Jr GJ, Schwartz AL. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Proc Natl Acad Sci USA 1994; 91: 6664-6668
    CrossrefPubMedGoogle Scholar
  • 106 Rao LVM, Nordfang O, Hoang AD, Pendurthi UR. Mechanism of antithrombin III inhibition of VIIa/tissue factor activity on cell surfaces. Comparison with tissue factor pathway inhibitor/factor Xa induced inhibition of factor VIIa/tissue factor activity. Blood 1995; 85: 121-129
    PubMedGoogle Scholar
  • 107 Sandset PM, Warn-Cramer BJ, Rao LVM, Maki SL, Rapaport SI. Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: Evidence supporting a physiologic role for EPI as a natural anticoagulant. Proc Natl Acad Sci USA 1991; 88: 708-712
    CrossrefPubMedGoogle Scholar
  • 108 Sandset PM, Wam-Cramer BJ, Maki SL, Rapaport SI. Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. Blood 1991; 78: 1496
    PubMedGoogle Scholar
  • 109 Loeliger EA, van der Esch B, Cleton FJ, Booji HL, Mattem MJ. On the metabolism of factor VII. In: Proceedings of the 7th Congress of the European Society of Haematology. London: 1959: 764-772
    Google Scholar
  • 110 Almus FE, Rao LVM, Fleck RA, Rapaport SI. Properties of factor VIIa/tissue factor complexes in an umbilical vein model. Blood 1990; 76: 354-360
    PubMedGoogle Scholar
  • 111 Rapaport SI, Hjort PF, Patch MJ. Further evidence that thrombin-activation of factor VIII is an essential step in intrinsic clotting. Scand J Clin Lab Invest 1965; 17 (84) 88-100
    PubMedGoogle Scholar
  • 112 Koedam JA, Hamer RJ, Beeser-Visser NH, Bouma BN, Sixma JJ. The effect of von Willebrand factor on activation of factor VIII by factor Xa. Eur J Biochem 1990; 189: 229-234
    CrossrefPubMedGoogle Scholar
  • 113 Pieters J, Lindhout T, Hemker HC. In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. Blood 1989; 74: 1021-1024
    CrossrefPubMedGoogle Scholar
  • 114 Lenting PJ, Donath MJSH, van Mourik JA, Mertens K. Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII. J Biol Chem 1994; 269: 7150-7155
    PubMedGoogle Scholar
  • 115 Fay PF. Factor VIII structure and function. Thromb Haemostas 1993; 70: 63-67
    PubMedGoogle Scholar
  • 116 Devaux PF. Static and dynamic lipid asymmetry in cell membranes. Biochem 1991; 30: 1163-1173
    CrossrefPubMedGoogle Scholar
  • 117 Gordon SG, Chelladurai M. Non-tissue factor procoagulants in cancer cells. Cancer Metastasis Rev 1992; 11: 267-282
    CrossrefPubMedGoogle Scholar
  • 118 Falanga A, Gordon SG. Isolation and characterization of cancerprocoagulant: a cysteine proteinase from malignant tissue. Biochem 1985; 24: 5558-5567
    CrossrefPubMedGoogle Scholar
  • 119 Novotny WF. Tissue factor pathway inhibitor. Semin Thromb Hemost 1994; 20: 101-108
    Article in Thieme ConnectPubMedGoogle Scholar
  • 120 Warr TA, Rao LVM, Rapaport SI. Human plasma extrinsic pathway inhibitor activity: II. Plasma levels in disseminated intravascular coagulation and hepatocellular disease. Blood 1989; 74: 994-998
    PubMedGoogle Scholar
  • 121 Day KC, Hoffman LC, Palmier MO, Kretzmer KK, Huang MD, Pyla EY, Spokas E, Broze Jr GJ, Warren TG, Wun TC. Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit. Blood 1990; 76: 1538-1545
    PubMedGoogle Scholar
  • 122 Bregengard C, Nordfang O, Wildgoose P, Svendsen O, Hedner U, Diness V. The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits. Blood Coagul Fibrinolysis 1993; 4: 699-706
    CrossrefPubMedGoogle Scholar
  • 123 Creasey AA, Chang ACK, Feigen L, Wun TC, Taylor FB, Hinshaw LB. Tissue factor pathway inhibitor reduces mortality from E. coli septic shock. J Clin Invest 1993; 91: 2850-2860
    CrossrefPubMedGoogle Scholar
  • 124 Sack GH, Levin J, Bell WR. Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977; 56: 1-37
    CrossrefPubMedGoogle Scholar
  • 125 Bell WR, Starksen NF, Tong S, Porterfield JK. Trousseau’s syndrome: Devasting coagulopathy in the absence of heparin. Am J Med 1985; 79: 423-430
    CrossrefPubMedGoogle Scholar
  • 126 Szczepanski M, Bardadin K, Zawadzki J, Pypno W. Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent. J Cancer Res Clin Oncol 1988; 114: 519-522
    CrossrefPubMedGoogle Scholar
  • 127 Gonmori H, Maekawa T, Kobayashi N, Tanaka H, Tsukada H, Takada M, Andou K. The role of tissue thromboplastin in the development of DIC accompanying neoplastic diseases. Bibl Haematol 1983; 49: 23-29
    PubMedGoogle Scholar
  • 128 Callander NS, Varki N, Rao LVM. Immunohistochemical identification of tissue factor in solid tumors. Cancer 1992; 70: 1194-1201
    CrossrefPubMedGoogle Scholar
  • 129 Callander N, Rapaport SI. Trousseau's syndrome. West J Med 1993; 158: 364-371
    PubMedGoogle Scholar
  • 130 Rao LVM. Tissue factor as a tumor procoagulant. Cancer and Metastasis Reviews 1992; 11: 249-266
    CrossrefPubMedGoogle Scholar
  • 131 Zivelin A, Rao LVM, Rapaport SI. Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors. J Clin Invest 1993; 92: 2131-2140
    CrossrefPubMedGoogle Scholar
  • 132 Zivelin A, Rao LVM, Rapaport SI. Evidence for an essential role of tissue factor dependent blood coagulation in the pathogenesis of local Shwartzman reaction. Blood Cells, Molecules & Diseases 1995; 21: 9-19
    CrossrefPubMedGoogle Scholar
  • 133 Broze Jr GJ. Why do hemophiliacs bleed?. Hosp Pract 1995; 27: 71-86
    PubMedGoogle Scholar
  • 134 Erhardsten E, Madsen M, Ezban M, Hedner U, Diness V, Glazer S, Nordfang O. Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced hemophilia A. Thromb Haemostas 1993; 69: 52 (Abstract)
    PubMedGoogle Scholar
  • 135 Gailani D, Broze Jr GJ. Factor XII-independent activation of factor XI in plasma: Effects of sulfatides on tissue factor-induced coagulation. Blood 1993; 82: 813-819
    PubMedGoogle Scholar
  • 136 von dem Borne PA, Koppelman SJ, Bouma BN, Meijers JCM. Surface independent factor XI activation by thrombin in the presence of high molecular weight kininogen. Thromb Haemostas 1994; 72: 397-402
    PubMedGoogle Scholar
  • 137 Hedner U. Factor VIIa in the treatment of haemophilia. Blood Coagul Fibrinolysis 1990; 1: 307-317
    CrossrefPubMedGoogle Scholar
  • 138 Rao LVM, Rapaport SI. Factor VIIa-catalyzed activation of factor X independent of tissue factor: Its possible significance for control of hemophilic bleeding by infused factor VIIa. Blood 1990; 75: 1069-1973
    PubMedGoogle Scholar
  • 139 Hoffman M, Monroe DM, Roberts HR. Human monocytes support factor X activation by factor VIIa, independent of tissue factor: Implications for the therapeutic mechanism of high-dose factor VIIa in hemophilia. Blood 1994; 83: 38-42
    PubMedGoogle Scholar
  • 140 Ten Cate H, Bauer K, Levi M, Edgington TS, Sublett RD, Barzegar S, Kass B, Rosenberg RD. The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor. J Clin Invest 1993; 92: 1207-1212
    CrossrefPubMedGoogle Scholar
  • 141 Sakai T, Lund-Hansen T, Paborsky L, Pedersen AH, Kisiel W. Binding of human factors VII and VIIa to a human bladder carcinoma cell line (J82) implications for the initiation of the extrinsic pathway of blood coagulation. J Biol Chem 1989; 264: 9980-9988
    PubMedGoogle Scholar
  • 142 Godal HC, Madsen K, Nissen-Meyer R. Thrombo-embolism in patients with total proconvertin (factor VII) deficiency: A report on two cases. Acta Med Scand 1962; 171: 325-327
    PubMedGoogle Scholar
  • 143 Hall CA, Rapaport SI, Ames SB, Degroot JA. A clinical and family study of hereditary proconvertin (factor VII) deficiency. Am J Med 1964; 37: 172-181
    CrossrefPubMedGoogle Scholar
  • 144 Greshwin ME, Gude JK. Deep vein thrombosis and pulmonary embolism in congenital factor VII deficiency. N Engl J Med 1973; 288: 141-142
    CrossrefPubMedGoogle Scholar
  • 145 Meade TW, Ruddock V, Stirling Y, Chakrabarti R, Miller GJ. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park heart study. Lancet 1993; 342: 1076-1079
    CrossrefPubMedGoogle Scholar
  • 146 Heinrich J, Balleisen L, Schulte H, Assmann G, van de Loo J. Fibrinogen and factor VII in the prediction of coronary risk. Arterioscler Thromb 1994; 14: 54-59
    CrossrefPubMedGoogle Scholar
  • 147 Allien DC, Morrissey JH, Edgington TS. Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: An alternative initiation of the coagulation protease cascade. Proc Natl Acad Sci USA 1988; 85: 7462-7466
    CrossrefPubMedGoogle Scholar