Plasminogen San Antonio: An Abnormal Plasminogen with a More Cathodic Migration, Decreased Activation and Associated Thrombosis

Ying Liu; Roger M Lyons; Jan McDonagh

doi:10.1055/s-0038-1642564

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 59(01): 049-053
DOI: 10.1055/s-0038-1642564

Review Article

Schattauer GmbH Stuttgart

Plasminogen San Antonio: An Abnormal Plasminogen with a More Cathodic Migration, Decreased Activation and Associated Thrombosis

Ying Liu

¹The Department of Pathology, Beth Israel Hospital and Harvard Medical School and the Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA and Southwest Texas Methodist Hospital, San Antonio, TX, USA

,

Roger M Lyons

¹The Department of Pathology, Beth Israel Hospital and Harvard Medical School and the Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA and Southwest Texas Methodist Hospital, San Antonio, TX, USA

,

Jan McDonagh

¹The Department of Pathology, Beth Israel Hospital and Harvard Medical School and the Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA and Southwest Texas Methodist Hospital, San Antonio, TX, USA

› Author Affiliations

Abstract

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Summary

An abnormal plasminogen (San Antonio) has been isolated from a patient with axillary vein thrombosis. A decreased level of fibrinolytic activity was detected in both plasma and a purified system. The molecular abnormalities were investigated with both functional and immunological tests. Slightly decreased antigen concentration was noted in plasma. By crossed immunoelec-trophoresis, the patient and his two children had a second small arc and the primary arc migrated more eathodically. A distinct isozyme was detected in the abnormal plasminogen. Functionally, this abnormal plasminogen is characterized by failure to enhance maximal conversion to plasmin, especially by plasminogen activators, which are enhanced by fibrin or fibrin degradation products. The proband and his children are heterozygous for this abnormal plasminogen.

Keywords

Abnormal plasminogen - Axillary vein thrombosis - Fibrinolysis

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References

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