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Thromb Haemost 1994; 71(03): 398-399
DOI: 10.1055/s-0038-1642450
Letter to the editor
Schattauer GmbH Stuttgart

Is the Increase in Plasma von Willebrand Factor Concentrations in Diabetes mellitus Related to Insulin Levels?

Coen D A Stehouwer
Dept of Internal Medicine, Institute for Cardiovascular Research, Free University Hospital, 1081HV Amsterdam, The Netherlands
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Further Information

Publication History

Received: 10 September 1993

Accepted after revision 10 November 1993

Publication Date:
06 July 2018 (online)

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  • References

  • 1 Conlan MG, Folsom AR, Finch A, Davis CE, Sorlie F, Marcucci U, Wu KK. Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb Haemostas 1993; 70: 380-5
    PubMedGoogle Scholar
  • 2 DeFronzo RA, Ferranini E. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-94
    PubMedGoogle Scholar
  • 3 Jensen T. Increased plasma level of von Willebrand factor in type 1 (insulin-dependent) diabetic patients with incipient nephropathy. BMJ 1989; 298: 27-8
    PubMedGoogle Scholar
  • 4 Stehouwer CDA, Stroes ESG, Hackeng WHL, Mulder PGH, den Otto-lander GJH. von Willebrand factor and development of diabetic nephropathy in insulin-dependent diabetes mellitus. Diabetes 1991 40: 971-6 erratum Diabetes 1991; 40: 1746
    PubMedGoogle Scholar
  • 5 Stehouwer CDA, Nauta JJP, Zeldenrust GC, Hackeng WHL, Donker AJM, den Ottolander GJH. Albuminuria, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus. Lancet 1992; 340: 319-23
    CrossrefPubMedGoogle Scholar
  • 6 Collier A, Rumley A, Rurnley AG, Paterson JR, Leach JP, Lowe GDO, Small M. Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. Diabetes 1992; 41: 909-13
    CrossrefPubMedGoogle Scholar
  • 7 Stehouwer CDA, Zellenrath P, Polak BCP, Baarsma GS, Nauta JJP, Donker AJM, den Ottolander GJH. von Willebrand factor and early diabetic retinopathy: no evidence for a relationship in patients with Type 1 (insulin-dependent) diabetes mellitus and normal urinary albumin excretion. Diabetologia 1992; 35: 555-9
    CrossrefPubMedGoogle Scholar
  • 8 Stehouwer CDA, Donker AJM. Urinary albumin excretion and cardiovascular disease risk in diabetes mellitus: is endothelial dysfunction the missing link?. J Nephrol 1993; 6: 72-92
    PubMedGoogle Scholar
  • 9 Groop L, Ekstrand A, Forsblom C, Widén E, Groop PH, Teppo AM, Eriksson J. Insulin resistance, hypertension and microalbuminuria in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1993; 36: 642-7
    CrossrefPubMedGoogle Scholar
  • 10 Vane JR, Ånggård EE, Botting RM. Mechanisms of disease: regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27-36
    CrossrefPubMedGoogle Scholar