Thromb Haemost 1994; 71(03): 284-285
DOI: 10.1055/s-0038-1642431
Original Article
Schattauer GmbH Stuttgart

Effects of Low Intensity Antithrombotic Regimes on the Haemoglobin Level

T W Meade
The MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, The Medical College of St Bartholomew's Hospital, London, UK
,
D J Howarth
The MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, The Medical College of St Bartholomew's Hospital, London, UK
,
P J Brennan
The MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, The Medical College of St Bartholomew's Hospital, London, UK
› Author Affiliations
Further Information

Publication History

Received: 10 August 1993

Accepted after revision 10 October 1993

Publication Date:
06 July 2018 (online)

Summary

The effects on the haemoglobin level of low dose aspirin and of low intensity oral anticoagulation with warfarin separately and in combination have been established in men aged between 45 and 69 at high risk of ischaemic heart disease. The findings confirm that combined treatment with warfarin and aspirin (WA) leads to a clear excess of minor bleeding episodes over warfarin alone (W) or aspirin alone (A). Each separate treatment on its own (either W or A) leads to an increase in these episodes compared with those on placebo (P) treatment. However, neither combined treatment (WA) nor the separate treatments (W or A) cause a fall in haemoglobin levels over a period of up to two years.