Thromb Haemost 1994; 71(03): 275-279
DOI: 10.1055/s-0038-1642429
Original Article
Schattauer GmbH Stuttgart

Increased Tissue Factor Pathway Inhibitor Levels in Uremic Patients on Regular Hemodialysis

Kazuomi Kario
1  The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Hyogo, Japan
2  The Department of Internal Medicine, Awaji-Flokutan Public Clinic, Hokutan, Tsuna, Hyogo, Japan
,
Takefumi Matsuo
1  The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Hyogo, Japan
,
Tsutomu Yamada
1  The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Hyogo, Japan
,
Miyako Matsuo
1  The Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto, Hyogo, Japan
› Author Affiliations
Further Information

Publication History

Received: 29 July 1993

Accepted after revision 16 December 1993

Publication Date:
06 July 2018 (online)

Summary

We investigated tissue factor pathway inhibitor (TFPI) levels in 44 non-dialysis uremic patients and 36 chronic dialysis patients, as well as the changes of TFPI levels during hemodialysis sessions using heparin (n = 14), low molecular weight heparin (n = 7), nafamostat mesilate (n = 5), and argatroban (n = 2). In non-dialysis uremic patients, TFPI levels increased (mean ± SD: 178 ± 37% of control pooled plasma) along with the impairment of renal function. In chronic hemodialysis patients, TFPI levels were even higher (265 ± 72%) before dialysis, but did not depend on the etiology of renal failure (diabetic or non-diabetic), the interval between dialysis sessions (twice or three times a week), and the duration of hemodialysis. During hemodialysis sessions using heparin, TFPI levels increased 1.2-to 3.5-fold compared with the level before hemodialysis and the degree of increase in TFPI was correlated with the heparin concentration (r = 0.648, p = 0.0001, n = 29). During dialysis sessions using low molecular weight heparin, TFPI levels also increased, but the change was less marked than during dialysis with heparin. TFPI levels did not change during dialysis sessions using nafamostat mesilate or argatroban. In conclusion, TFPI levels were increased by renal failure and by long-term repeated injection of heparin, but the hemodialysis procedure itself did not alter the TFPI level.