CC-BY 4.0 · TH Open 2018; 02(02): e131-e138
DOI: 10.1055/s-0038-1641678
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort

Inger Lise Gade
1  Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
,
Sigrid K. Brækkan
2  Department of Clinical Medicine, K.G Jebsen Thrombosis Research and Expertise Centre (TREC), University of Tromsø—The Arctic University of Norway, Tromsø, Norway
3  Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
,
Inger Anne Næss
4  Department of Haematology, Trondheim University Hospital, Trondheim, Norway
,
John-Bjarne Hansen
2  Department of Clinical Medicine, K.G Jebsen Thrombosis Research and Expertise Centre (TREC), University of Tromsø—The Arctic University of Norway, Tromsø, Norway
3  Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway
,
Suzanne C. Cannegieter
5  Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
,
Frits R. Rosendaal
5  Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
,
Kim Overvad
6  Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
7  Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
,
Kristian Hindberg
2  Department of Clinical Medicine, K.G Jebsen Thrombosis Research and Expertise Centre (TREC), University of Tromsø—The Arctic University of Norway, Tromsø, Norway
,
Jens Hammerstrøm
8  Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
,
Olga V. Gran
2  Department of Clinical Medicine, K.G Jebsen Thrombosis Research and Expertise Centre (TREC), University of Tromsø—The Arctic University of Norway, Tromsø, Norway
,
Anne Tjønneland
9  Department of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
,
Marianne T. Severinsen
1  Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
10  Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
,
Søren R. Kristensen
1  Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
11  Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
› Author Affiliations
Funding K.G. Jebsen Thrombosis Research and Expertise Center (TREC) received an independent research grant from Stiftelsen Kristian Gerhard Jebsen. Professor S.R. Kristensen received an independent research grant from The Obel Family Foundation and from the Danish Council for Independent Research.
Further Information

Publication History

21 November 2017

19 February 2018

Publication Date:
06 April 2018 (online)

Abstract

The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely investigated. The aim of the study was to investigate if incidence rates (IRs) of VTE differed in patients who were alive at least 2 years after a cancer diagnosis without VTE compared with cancer-free references in a population-based cohort study. The study entry was 2 years after a first cancer diagnosis. For each cancer-exposed subject, five reference subjects were identified within the cohort. The IRs were calculated as number of VTEs per 1,000 person years (×10−3 p-y) in total and in distinct cancer types and corresponding reference subjects. Incidence rate ratios (IRRs) were calculated by Poisson's regression. During a mean follow-up of 5.3 years, 110 VTEs occurred among the 7,288 cancer-exposed subjects and 321 VTEs occurred among the 36,297 identified reference subjects. The IR of VTE was higher for cancer-exposed subjects compared with reference subjects, IRs 3.7 × 10−3 p-y, 95% CI: 3.1 to 4.5 and 1.9 × 10−3 p-y, 95% CI: 1.7 to 2.2, respectively. IRs of VTE in most solid cancer types declined to almost the same level as in the reference subjects 2 years after cancer diagnosis, but remained higher in hematological cancers, IRR 4.0, 95% CI: 2.0 to 7.8.