J Neurol Surg B Skull Base 2018; 79(06): 515-521
DOI: 10.1055/s-0038-1635077
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Outcomes of Craniofacial Open Surgery in Octogenarians

Barak Ringel
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Narin N. Carmel-Neiderman
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Daniel Ben-Ner
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Aviyah Pery
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Ahmad Safadi
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Avraham Abergel
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Nevo Margalit
2   Departments of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Dan M. Fliss
1   Departments of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
› Author Affiliations
Further Information

Publication History

07 October 2017

13 January 2018

Publication Date:
09 March 2018 (online)

Abstract

Introduction The steady increase in average life expectancy has led to a rise in the number of referrals of elderly patients for major operations. It is not clear whether age itself is a risk factor for morbidity and mortality after skull base operations. We investigated a possible link among a cohort of patients older than 80 years of age who underwent those surgeries in our department.

Methods We conducted a retrospective analysis of all patients who underwent skull base surgery at the TASMC (Tel Aviv Sourasky Medical Center) between 2000 and 2016.

Results A total of 369 patients underwent open skull base surgeries in our institution, and 13 were patients older than 80 years. The median age of the octogenarians was 83.4 (range 80–89), and the male-to-female ratio was 7:6. Twelve patients had major systemic comorbidities. Four patients had major complications associated with surgery: three had early wound complications, and one each had early central nervous system complications, early and late systemic complications, and late orbital complications. This complication rate is comparable to that of our younger group of 356 patients. The overall survival rate was measured for 30 days, 1 year, and 3 years, and it was not significantly different between the octogenarians and that of the younger patients. Further comparison of the elderly group with 13 matched younger patients revealed no difference of morbidity and mortality between the two groups.

Conclusions Despite their systemic comorbidities, the morbidity and mortality rates associated with skull base surgery in octogenarians appear to be comparable to that of younger patients undergoing the same procedures.

 
  • References

  • 1 Fentiman IS, Tirelli U, Monfardini S. , et al. Cancer in the elderly: why so badly treated?. Lancet 1990; 335 (8696): 1020-1022
  • 2 Kennedy BJ. Aging and cancer. Oncology (Williston Park) 2000; 14 (12) 1731-1733 , discussion 1734, 1739–1740
  • 3 Repetto L, Comandini D, Mammoliti S. Life expectancy, comorbidity and quality of life: the treatment equation in the older cancer patients. Crit Rev Oncol Hematol 2001; 37 (02) 147-152
  • 4 World Population Prospects. The 2015 Revision. In: United Nations, Department of Economic and Social Affairs, Population Division; 2015. https://esa.un.org/unpd/wpp/publications/files/key_findings_wpp_2015.pdf . Accessed March 5, 2018
  • 5 Ganly I, Patel SG, Singh B. , et al. Craniofacial resection for malignant tumors involving the skull base in the elderly: an international collaborative study. Cancer 2011; 117 (03) 563-571
  • 6 Grammatica A, Piazza C, Paderno A, Taglietti V, Marengoni A, Nicolai P. Free flaps in head and neck reconstruction after oncologic surgery: expected outcomes in the elderly. Otolaryngol Head Neck Surg 2015; 152 (05) 796-802
  • 7 Hamel MB, Henderson WG, Khuri SF, Daley J. Surgical outcomes for patients aged 80 and older: morbidity and mortality from major noncardiac surgery. J Am Geriatr Soc 2005; 53 (03) 424-429
  • 8 Turrentine FE, Wang H, Simpson VB, Jones RS. Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg 2006; 203 (06) 865-877
  • 9 Ganly I, Gross ND, Patel SG, Bilsky MH, Shah JP, Kraus DH. Outcome of craniofacial resection in patients 70 years of age and older. Head Neck 2007; 29 (02) 89-94
  • 10 Khafif A, Posen J, Yagil Y. , et al. Quality of life in patients older than 75 years following major head and neck surgery. Head Neck 2007; 29 (10) 932-939
  • 11 Yang R, Lubek JE, Dyalram D, Liu X, Ord RA. Head and neck cancer surgery in an elderly patient population: a retrospective review. Int J Oral Maxillofac Surg 2014; 43 (12) 1413-1417
  • 12 Patil VM, Noronha V, Joshi A. , et al. Neoadjuvant chemotherapy in geriatric head and neck cancers. Head Neck 2017; 39 (05) 886-892
  • 13 Syrigos KN, Karachalios D, Karapanagiotou EM, Nutting CM, Manolopoulos L, Harrington KJ. Head and neck cancer in the elderly: an overview on the treatment modalities. Cancer Treat Rev 2009; 35 (03) 237-245
  • 14 VanderWalde NA, Fleming M, Weiss J, Chera BS. Treatment of older patients with head and neck cancer: a review. Oncologist 2013; 18 (05) 568-578
  • 15 Siddiqui F, Gwede CK. Head and neck cancer in the elderly population. Semin Radiat Oncol 2012; 22 (04) 321-333
  • 16 Clayman GL, Eicher SA, Sicard MW, Razmpa E, Goepfert H. Surgical outcomes in head and neck cancer patients 80 years of age and older. Head Neck 1998; 20 (03) 216-223
  • 17 Hentschel SJ, Nader R, Suki D, Dastgir A, Callender DL, DeMonte F. Craniofacial resections in the elderly: an outcome study. J Neurosurg 2004; 101 (06) 935-943
  • 18 Lalami Y, de Castro Jr G, Bernard-Marty C, Awada A. Management of head and neck cancer in elderly patients. Drugs Aging 2009; 26 (07) 571-583