Download PDF
Vet Comp Orthop Traumatol 1991; 4(03): 95-99
DOI: 10.1055/s-0038-1633260
Original Research
Schattauer GmbH

Aspirin Medication in Dogs

The Influences of Tablet Type and Feeding Regimen on Plasma Salicylate Concentrations
R. C. Nap
1   From the Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
,
I. O. M. Peters
1   From the Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
,
A. Willemsen
1   From the Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
,
J. J. de Bruyne
1   From the Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received for publication 20 December 1990

Publication Date:
06 February 2018 (online)

    Permissions and Reprints

Summary

Aspirin (acetylsalicylic acid; ASA) is widely used in both human and veterinary medicine. Therapeutic plasma salicylate concentrations (PSCs) can be reached using enteric-coated ASA tablets, but a delay in the initial rise and large fluctuations in the PSCs have been reported. From experiments described previously, the authors concluded that the large type enteric-coated ASA tablets were not suitable for use in beagle dogs.

In the first experiment described here, these large type tablets were administered to large mongrel dogs. Although the mean PSC reached therapeutic levels after 44 h, in individual dogs subtherapeutic concentrations were frequently recorded. In the second experiment microgranulated type enteric-coated ASA tablets were given to beagle dogs in a crossover design study. PSCs in all dogs exceeded minimal therapeutic levels 6 h after tablet administration. Stable therapeutic PSCs were found in both groups on different feeding regimens. In the third experiment the two types of enteric-coated ASA tablets were administered to fasting beagles. Comparable therapeutic PSCs were reached with both formulations.

From the present studies it can be concluded that the large type enteric-coated ASA tablet is not suitable for use in large mongrel dogs. Secondly, it can be concluded that the microgranulated type enteric-coated ASA tablet is suitable for the use in beagle dogs. In the third experiment it was proven that fasting eliminated the differences in mean PSC curves between the two types of ASA medication.

On the basis of canine gastric physiology the authors expect similar types of large enteric-coated tablets of other drugs to generate comparably poor plasma concentrations. The gastric evacuation of tablets is primarily related to the tablet dimensions and digestibility, and not to the drug contained by these tablets.

Keywords

Aspirin - enteric-coated tablet - dog
 

  • References

  • 1 Chastain CB. Aspirin: New indications for an old drug. Comp Cont Ed 1987; 9: 165-70..
    PubMedGoogle Scholar
  • 2 Davis LE. Clinical pharmacology of salicylates. J Am Vet Med Assoc 1980; 176: 65-6..
    PubMedGoogle Scholar
  • 3 Yeary RA, Brant RJ. Aspirin dosages for the dog. J Am Vet Med Assoc 1975; 167: 63-4..
    PubMedGoogle Scholar
  • 4 Lipowitz AJ, Boulay JP, Klausner JS. Serum salicylate concentrations and endoscopic evaluation of gastric mucosa in dogs after oral administration of aspirin-containing products. Am J Vet Res 1986; 47: 1586-9..
    PubMedGoogle Scholar
  • 5 Bonneau NH, Reed JH, Pennock PW, Little PB. Comparison of gastrophotography and contrast radiography for diagnosis of aspirin induced gastritis in the dog. J Am Vet Med Assoc 1972; 161: 190-8..
    PubMedGoogle Scholar
  • 6 Davison C, Hertig DH, DeVine R. Gastric hemorrhage induced by nonnarcotic analgetic agents in dogs. Clin Pharmacol Ther 1966; 7: 239-49..
    CrossrefPubMedGoogle Scholar
  • 7 Lanza FL, Royer GL, Nelson RS. Endoscopic evaluation of the effects of aspirin, buffered aspirin and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980; 303: 136-8..
    CrossrefPubMedGoogle Scholar
  • 8 Leonards JR, Levy G. Absorption and metabolism of aspirin administered in enteric-coated tablets. J Am Med Assoc 1965; 193: 93-8..
    PubMedGoogle Scholar
  • 9 Burrows CF, Bright RM, Spencer CP. Influence of dietary composition on gastric emptying and motility in dogs: potential involvement in acute gastric dilatation. Am J Vet Res 1985; 46: 2609-12..
    PubMedGoogle Scholar
  • 10 Hall JA, Burrows CF, Twedt DC. Gastric motility in dogs. Part I: Normal gastric function. Comp Cont Ed 1988; 10: 1282-93..
    PubMedGoogle Scholar
  • 11 Hinder RA, Kelly KA. Canine gastric emptying of solids and liquids. Am J Physiol 1977; 233: E335-40..
    PubMedGoogle Scholar
  • 12 Kruiningen HJ, Wojan LD, Stake PE, Lord PF. The influence of diet and feeding frequency on gastric function in the dog. J Am An Hosp Assoc 1987; 23: 145-53..
    PubMedGoogle Scholar
  • 13 Prove J, Ehrlein HJ. Motor function of gastric antrum and pylorus for evacuation of low and high viscosity meals in dogs. Gut 1982; 23: 150-6..
    CrossrefPubMedGoogle Scholar
  • 14 Nap RC, Breen DJ, Lam TJGM, DeBruyne JJ. Gastric retention of enteric-coated aspirin tablets in beagle dogs. J Vet Pharmacol Ther 1990; 13: 148-53..
    CrossrefPubMedGoogle Scholar
  • 15 Code CF, Marlett JA. The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol 1975; 246: 289-309..
    CrossrefPubMedGoogle Scholar
  • 16 Banta CA, Clemens ET, Krisky MM, Sheffy BE. Sites of organic acid production and patterns of digestal movements in the gastrointestinal tract of dogs. J Nutr 1979; 109: 1592-600..
    CrossrefPubMedGoogle Scholar
  • 17 Kelly KA. Motility of the stomach and gastroduodenal junction. In: Physiology of the Gastrointestinal Tract. Johnson LR. (ed). New York: Raven Press; 1981: 197-241.
    Google Scholar
  • 18 Anslow JA, Greene DS, Hooper JW, Wagner GS. Faster and more reliable delivery of salicylic acid from enteric-coated aspirin granules versus enteric-coated aspirin tablets. Curr Therapeutic Res 1984; 36: 811-8..
    PubMedGoogle Scholar
  • 19 Trinder P. Rapid determination of salicylate in biological fluids. Biochem J 1954; 57: 301-3..
    CrossrefPubMedGoogle Scholar
  • 20 Richez P, Regnier A, Ruckebush Y. Influence of food intake on the absorption of lysine-acetylsalicylate in dogs. J Vet Pharmacol Ther 1980; 3: 121-4..
    CrossrefPubMedGoogle Scholar