Villonodular synovitis in the dog

Summary

Four cases of villonodular synovitis were diagnosed by histopathology. All four dogs were treated medically with either carprophen or a combination of carprophen and glucosamine complex (Cosequin®). In three of the dogs the condition improved significantly, and these dogs returned to normal workload.

Keywords

Villonodular synovitis - arthroscopy - medical treatment - shoulder joint - stifle joint - dog

• References

• 1 Atmore WG. et al. Pigmented villonodular synovitis. Minn Med 1956; 39: 196-202.
• 2 Barclay WP. et al. Equine villonodular synovitis: A case survey. Cornell Vet 1980; 70: 72-6.
• 3 Berger I. et al. Comparative analysis of cell populations involved in the proliferative and inflammatory process in diffuse and localised pigmented villonodular synovitis. Histol Histopathol 2004; 19: 687-92.
• 4 Bhawan J. et al. Microcirculatory changes in posttraumatic pigmented villonodular synovitis. Arch Pathol Lab Med 1980; 104: 328-32.
• 5 Bhimani MA. et al. Pigmented villonodular synovitis: keys to early diagnosis. Clin Orthop Relat Res 2001; 197-202.
• 6 Brien EW. et al. Pigmented villonodular synovitis of the foot and ankle. Foot Ankle Int 2004; 25: 908-13.
• 7 Byers PD. et al. The diagnosis and treatment of pigmented villonodular synovitis. J Bone Joint Surg (Br) 1968; 50: 290-304.
• 8 Chin KR. et al. Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee. J Bone Joint Surg (Am) 2002; 84: 2192-202.
• 9 Chung SM, Janes JM. Diffuse pigmented villonodular synovitis of the hip joint. J Bone Joint Surg (Am) 1965; 47: 292-6.
• 10 Cohen AS. et al. Tumours ofjoints and related structures. In: Arthritis and allied conditions. (A textbook of rheumatology). McCarthy DJ. (ed) Philadelphia: Lea&Febiger; 1985: 1309-21.
• 11 Darling JM. et al. Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. Am J Pathol 1997; 150: 1383-93.
• 12 De Ponti A. et al. Result of arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthroscopy 2003; 19: 602-7.
• 13 Fechner RE. Neoplasms and neoplasm-like lesions of synovium. In: Bones and Joints. Ackerman LV Spjut HJ, Abell MR (eds). Baltimore: Williams & Wilkins 1976; 157-81.
• 14 Flandry FC. et al. Surgical treatment of diffuse pigmented villonodular synovitis of the knee. Clin Orthop Res 1994; 300: 183-92.
• 15 Gehweiler JA. et al. Diffuse biarticular pigmented villonodular synovitis. Radiology 1969; 93: 845-51.
• 16 Greenfield MM. et al. Pigmented villonodular synovitis. Radiology 1950; 54: 350-6.
• 17 Gumpel JM. et al. Diffuse pigmented villonodular synovitis: Non-surgical management. Ann Rheum Dis 1991; 50: 531-3.
• 18 Hanson JA. Radiographic diagnosis – canine carpal villonodular synovitis. Vet Rad Ultrasound 1998; 39: 15-7.
• 19 Hoaglund FT. Experimental hemarthrosis: The response of canine knees to injection of autogenous blood. J Bone Joint Surg (Am) 1967; 49: 285-97.
• 20 Jaffe HL. et al. Pigmented villonodular synovitis, bursitis and tenosynovitis. Arch Pathol 1941; 31: 731-65.
• 21 Kat S. et al. Radiosynovectomy in pigmented villonodular synovitis. Nuklearmedizin 2000; 39: 209-13.
• 22 Kroot EJ. et al. Tumournecrosis factor alphablockade in treatment resistant pigmented villonodular synovitis. Ann Rheum Dis 2005; 64: 497-9.
• 23 Kusba JK. et al. Suspected villonodular synovitis in adog. J Am Vet Med Assoc 1983; 182: 391-3.
• 24 Mackie CG. Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases. Clin Nucl Med 2003; 28: 881-5.
• 25 Marti JM. Bilateralpigmentedvillonodularsynovitis in a dog. J Small Anim Pract 1997; 38: 256-60.
• 26 Masih S. et al. Imaging of pigmented villonodular synovitis. Semin Musculoskelet Radiol 2003; 7: 205-16.
• 27 Möhler DG. et al. Open synovectomy with cryosurgical adjuvant for treatment of diffuse pigmented villonodular synovitis of the knee. Bull HospJtDis 2000; 59: 99-105.
• 28 Myers BW. et al. Pigmented villonodular synovitis and tenosynovitis: A clinical epidemiologic study of 166 cases and literature review. Medicine 1960; 59: 223-38.
• 29 Nickels FA. et al. Villonodular synovitis of the equine metacarpophalangeal joint. Am Assoc Equine Pract 1976; 21: 35-85.
• 30 Nilsonne Uetal. Pigmented villonodular synovitis of joints. Histological and clinical problems in diagnosis. Acta Orthop Scand 1969; 40: 448-60.
• 31 O'Keefe RJ. et al. Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Ortop J 1998; 18: 26-34.
• 32 Pool RR. et al. Tumors of joints. In: Tumors in domestic animals. Meuten DJ. (ed) Arnes. Iowa State Press; 2002: 201-3.
• 33 Rao AS. et al. Pigmented villonodular synovitis (giant cell tumor of the tendon sheath and synovial membrane). J Bone Joint Surg (Am) 1984; 66: 76-94.
• 34 Rauh PB. et al. Pigmented villonodular synovitis of the knee: average five-year follow-up of arthroscopic treatment. J South Orthop Assoc 2002; 11: 88-92.
• 35 Rose PL. Villonodular synovitis in horses. Comp Cont Ed Pract Vet 1988; 10: 649-54.
• 36 Scott PM. Bone lesions in pigmented villonodular synovitis. J Bone Joint Surg (Br) 1966; 50: 306-11.
• 37 Shabat Setal. The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. Rheumatology 2002; 41: 1113-8.
• 38 Smith JH. et al. Roentgenographs aspects of articular pigmented villonodular synovitis. Am Roentgenol 1962; 87: 1146-56.
• 39 Somer T. et al. Pigmented villonodular synovitis and plasmacytoid lymphoma in a dog. J Am Vet Med Assoc 1990; 197: 877-9.
• 40 Ucibori M. et al. Expression of matrix metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction. J Rheumatol 2004; 31: 110-9.
• 41 Yang PY. et al. Sonography of pigmented villonodular synovitis in the ankle joint. J Clin Ultrasound 1998; 26: 166-70.
• 42 Young JM. et al. Experimental production of pigmented villonodular synovitis in dogs. Am J Pathol 1954; 30: 799-811.