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Vet Comp Orthop Traumatol 2003; 16(01): 32-37
DOI: 10.1055/s-0038-1632752
Original Research
Schattauer GmbH

Histological features of osteoarthritic canine cartilage after prolonged administration of carprofen[*]

C. L. Dassler
1   Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, USA
,
S. M. Griffey
2   Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, USA
,
P. B. Vasseur
3   Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA
› Author Affiliations
Further Information

Publication History

Received 12 April 2002

Accepted 11 September 2002

Publication Date:
08 February 2018 (online)

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Summary

The objective of this study was to determine whether the non-steroidal anti-inflammatory drug (NSAID) carprofen causes adverse histological changes to cartilage after prolonged administration for treatment of naturally acquired osteoarthritis.

Dogs diagnosed with cranial cruciate ligament rupture and secondary osteoarthritis of their stifle joints were divided into two groups: those who had received a standard dose of carprofen for a minimum of four weeks and those who had not received a NSAID for a minimum of one month. Cartilage from the intercondylar notch was obtained when the patients underwent surgical procedures to stabilize the stifle joint. The samples were processed and evaluated for histological differences using haematoxylin and eosin and safranin-O-fast green-iron haematoxylin stains and were graded according to a Mankin scale (graded 0-14) for osteoarthritis.

The histopathological findings were variable and included loss of matrix staining, irregularities to the cartilage surface, matrix fragmentation, chondrocyte clustering, matrix degeneration and vascular and synovial invasion (pannus) and were not specific to either group. There was not any significant difference between study groups (p = 0.2721) according to the Wilcoxan rank sum test.

Keywords

Carprofen - osteoarthritis - cartilage - non-steroidal antiinflammatory drugs

* Work supported by a gift from Pfizer Pharmaceuticals.


 

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