Osteogenesis imperfecta in Three Dogs from a Single Litter

T. Lazar; J. J. deHaan; J. N. Peck; Bonnie G. Campbell; Pamela E. Ginn; Lynette Phillips; A. Suero; B. J. Chase

doi:10.1055/s-0038-1632625

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2000; 13(01): 23-27
DOI: 10.1055/s-0038-1632625

Clinical Communication

Schattauer GmbH

Osteogenesis imperfecta in Three Dogs from a Single Litter

Authors

T. Lazar

¹Afliliated Veterinary Specialists, P. A., Winter Park, Florida
J. J. deHaan

¹Afliliated Veterinary Specialists, P. A., Winter Park, Florida
J. N. Peck

¹Afliliated Veterinary Specialists, P. A., Winter Park, Florida
Bonnie G. Campbell

²Department of Biomedical Sciences, Cornell University, Ithaca, New York
Pamela E. Ginn

³Department of Pathobiology, University of Florida, Gainesville, Florida
Lynette Phillips

³Department of Pathobiology, University of Florida, Gainesville, Florida
A. Suero

⁴Tuscawilla Animal Hospital, Winter Springs, Florida
B. J. Chase

⁵Jewett Orthopaedic Clinic, Winter Park, Florida, U.S.A

Abstract

Summary

Three American Cream puppies from a litter of six were admitted for evaluation and treatment of lameness caused by multiple pathological fractures. Because of a poor prognosis, all three of the affected dogs were ultimately euthanatized. Based on the histopathological findings of the bones and a collagen analysis from cultured skin fibroblast cells which confirmed the presence of abnormal type I collagen, the presumptive diagnosis was osteogenesis imperfecta. In humans, more than 90% of the cases of osteogenesis imperfecta are caused by defects in type I collagen (11). Osteogenesis imperfecta has rarely been described in animals and none of the previous reports document the disease in more than one dog from a single litter.

Three American Cream puppies from a litter of six developed multiple pathologic features without a history of trauma. A diagnosis of osteogenesis imperfecta was made based on histopathology and results of type I collagen analysis from cultured skin fibroblasts.

Keywords

Osteogenesis imperfecta - collagen - dog

Full Text

References

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