High resolution peripheral quantitative computed tomography (HR-pQCT) und die klinische Relevanz der Resultate

Zusammenfassung

Knochenstabilität ist durch Knochenvolumen und Mikroarchitektur des Knochens determiniert. Mittels HR-pQCT (high resolution peripheral quantitative computed tomography) steht eine nicht invasive Methode zur Verfügung, um die Mikroarchitektur des Knochens darzustellen. Die Resultate aus zahlreichen Studien geben Rückschlüsse auf unterschiedliche Strukturalterationen im Rahmen von Erkrankungen, die mit einem erhöhten Frakturrisiko einhergehen. Die Knochendichtemessung mittels DXA spiegelt das Frakturrisiko oft nicht adäquat wider. Umso entscheidender ist es, Risikofaktoren in der Wahl der Therapie zu berücksichtigen. Die klinische Relevanz der Resultate aus HR-pQCT-Messungen besteht derzeit dahingehend, dass wertvolle Informationen über Veränderungen der Mikroarchitektur auf Forschungsebene erhoben werden.

Summary

Bone strength is determined of bone volume and bone microarchitecture. HR-pQCT (high resolution peripheral quantitative computed tomography) provides images of bone microarchitecture as a non-invasive method. In multiple studies structural alterations have been detected to be responsible for increased fracture risk in patients with diseases accompanied by increased fracture risk. The measurement of bone mineral density (BMD) with DXA often does not reflect the actual fracture risk. It is important to be aware of risk factors for increased fracture risk. The clinical relevance of the results of HR-pQCT is to provide more information about the pathogenesis of fractures and to provide data for clinical trials.

Schlüsselwörter

HR-pQCT - Mikroarchitektur - Frakturrisiko

Keywords

HR-pQCT - microarchitecture - fracture risk

• Literatur

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