Digestive Disease Interventions 2017; 01(04): 265-271
DOI: 10.1055/s-0038-1629915
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA

TIPS in the Treatment of Variceal Bleeding

Joseph D. Morrison
1   Division of Interventional Radiology, Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois
,
Andrew J. Lipnik
1   Division of Interventional Radiology, Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois
,
Ron C. Gaba
1   Division of Interventional Radiology, Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois
› Author Affiliations
Further Information

Publication History

26 July 2017

02 January 2018

Publication Date:
14 February 2018 (online)

Abstract

Variceal bleeding is a life-threatening complication of portal hypertension. In recent years, transjugular intrahepatic portosystemic shunt (TIPS) creation has cemented a role in the management of acute refractory bleeding and recurrent variceal hemorrhage. This article aims to review the use of TIPS in patients with variceal bleeding, with a focus on accepted procedure indications, patient selection criteria, TIPS technique, clinical outcomes, and contemporary issues, such as early TIPS in acute variceal hemorrhage, the role of adjuvant embolotherapy, and TIPS utility for gastric varices.

 
  • References

  • 1 Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985; 5 (03) 419-424
  • 2 Rajoriya N, Tripathi D. Historical overview and review of current day treatment in the management of acute variceal haemorrhage. World J Gastroenterol 2014; 20 (21) 6481-6494
  • 3 D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22 (01) 332-354
  • 4 Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med 2010; 362 (09) 823-832
  • 5 Tripathi D, Stanley AJ, Hayes PC. , et al; Clinical Services and Standards Committee of the British Society of Gastroenterology. U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 2015; 64 (11) 1680-1704
  • 6 Colapinto RF, Stronell RD, Birch SJ. , et al. Creation of an intrahepatic portosystemic shunt with a Grüntzig balloon catheter. Can Med Assoc J 1982; 126 (03) 267-268
  • 7 Colapinto RF, Stronell RD, Gildiner M. , et al. Formation of intrahepatic portosystemic shunts using a balloon dilatation catheter: preliminary clinical experience. AJR Am J Roentgenol 1983; 140 (04) 709-714
  • 8 Perry BC, Kwan SW. Portosystemic shunts: stable utilization and improved outcomes, two decades after the transjugular intrahepatic portosystemic shunt. J Am Coll Radiol 2015; 12 (12 Pt B): 1427-1433
  • 9 Boyer TD, Haskal ZJ. ; American Association for the Study of Liver Diseases. The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension: update 2009. Hepatology 2010; 51 (01) 306
  • 10 Dariushnia SR, Haskal ZJ, Midia M. , et al; Society of Interventional Radiology Standards of Practice Committee. Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 2016; 27 (01) 1-7
  • 11 Thabut D, Rudler M, Lebrec D. Early TIPS with covered stents in high-risk patients with cirrhosis presenting with variceal bleeding: are we ready to dive into the deep end of the pool?. J Hepatol 2011; 55 (05) 1148-1149
  • 12 Kovalak M, Lake J, Mattek N, Eisen G, Lieberman D, Zaman A. Endoscopic screening for varices in cirrhotic patients: data from a national endoscopic database. Gastrointest Endosc 2007; 65 (01) 82-88
  • 13 Grace ND. Prevention of initial variceal hemorrhage. Gastroenterol Clin North Am 1992; 21 (01) 149-161
  • 14 Burroughs AK, D'Heygere F, McIntyre N. Pitfalls in studies of prophylactic therapy for variceal bleeding in cirrhotics. Hepatology 1986; 6 (06) 1407-1413
  • 15 Merli M, Nicolini G, Angeloni S. , et al. Incidence and natural history of small esophageal varices in cirrhotic patients. J Hepatol 2003; 38 (03) 266-272
  • 16 Merkel C, Marin R, Angeli P. , et al; Gruppo Triveneto per l'Ipertensione Portale. A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology 2004; 127 (02) 476-484
  • 17 D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis 1999; 19 (04) 475-505
  • 18 Augustin S, Muntaner L, Altamirano JT. , et al. Predicting early mortality after acute variceal hemorrhage based on classification and regression tree analysis. Clin Gastroenterol Hepatol 2009; 7 (12) 1347-1354
  • 19 Reverter E, Tandon P, Augustin S. , et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology 2014; 146 (02) 412-19.e3
  • 20 Bañares R, Albillos A, Rincón D. , et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 2002; 35 (03) 609-615
  • 21 Njei B, McCarty TR, Laine L. Early TIPS in U.S. patients hospitalized with acute esophageal variceal bleeding. J Gastroenterol Hepatol 2017; 32 (04) 852-858
  • 22 Gaba RC, Couture PM, Bui JT. , et al. Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation. J Vasc Interv Radiol 2013; 24 (03) 411-420 , 420.e1–420.e4, quiz 421
  • 23 Gheorghe L, Iacob S, Iacob R, Gheorghe C, Popescu I. Variation of the MELD score as a predictor of death on the waiting list for liver transplantation. J Gastrointestin Liver Dis 2007; 16 (03) 267-272
  • 24 Gaba RC, Shah KD, Couture PM. , et al. Within-patient temporal variance in MELD score and impact on survival prediction after TIPS creation. Ann Hepatol 2013; 12 (05) 797-802
  • 25 Hausegger KA, Tauss J, Karaic K, Klein GE, Uggowitzer M. Use of the left internal jugular vein approach for transjugular portosystemic shunt. AJR Am J Roentgenol 1998; 171 (06) 1637-1639
  • 26 LaBerge JM, Ring EJ, Gordon RL. Percutaneous intrahepatic portosystemic shunt created via a femoral vein approach. Radiology 1991; 181 (03) 679-681
  • 27 Rees CR, Niblett RL, Lee SP, Diamond NG, Crippin JS. Use of carbon dioxide as a contrast medium for transjugular intrahepatic portosystemic shunt procedures. J Vasc Interv Radiol 1994; 5 (02) 383-386
  • 28 Farsad K, Fuss C, Kolbeck KJ. , et al. Transjugular intrahepatic portosystemic shunt creation using intravascular ultrasound guidance. J Vasc Interv Radiol 2012; 23 (12) 1594-1602
  • 29 Richter GM, Noeldge G, Roessle M, Palmaz JC. , Eds. Evolution and clinical introduction of TIPSS, the transjugular intrahepatic portosystemic stent-shunt. Seminars in Interventional Radiology; 1991. : Copyright© 1991 by Thieme Medical Publishers, Inc
  • 30 Harman JT, Reed JD, Kopecky KK, Harris VJ, Haggerty MF, Strzembosz AS. Localization of the portal vein for transjugular catheterization: percutaneous placement of a metallic marker with real-time US guidance. J Vasc Interv Radiol 1992; 3 (03) 545-547
  • 31 Wenz F, Nemcek Jr AA, Tischler HA, Minor PL, Vogelzang RL. US-guided paraumbilical vein puncture: an adjunct to transjugular intrahepatic portosystemic shunt (TIPS) placement. J Vasc Interv Radiol 1992; 3 (03) 549-551
  • 32 Warner DL, Owens CA, Hibbeln JF, Ray Jr CE. Indirect localization of the portal vein during a transjugular intrahepatic portosystemic shunt procedure: placement of a radiopaque marker in the hepatic artery. J Vasc Interv Radiol 1995; 6 (01) 87-89 , discussion 89–90
  • 33 Sommer CM, Gockner TL, Stampfl U. , et al. Technical and clinical outcome of transjugular intrahepatic portosystemic stent shunt: bare metal stents (BMS) versus Viatorr stent-grafts (VSG). Eur J Radiol 2012; 81 (09) 2273-2280
  • 34 Clark TW, Agarwal R, Haskal ZJ, Stavropoulos SW. The effect of initial shunt outflow position on patency of transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 2004; 15 (2 Pt 1): 147-152
  • 35 Riggio O, Ridola L, Angeloni S. , et al. Clinical efficacy of transjugular intrahepatic portosystemic shunt created with covered stents with different diameters: results of a randomized controlled trial. J Hepatol 2010; 53 (02) 267-272
  • 36 Miraglia R, Maruzzelli L, Tuzzolino F, Petridis I, D'Amico M, Luca A. Transjugular intrahepatic portosystemic shunts in patients with cirrhosis with refractory ascites: comparison of clinical outcomes by using 8- and 10-mm PTFE-covered stents. Radiology 2017; 284 (01) 281-288
  • 37 Gaba RC, Parvinian A, Minocha J. , et al. Should transjugular intrahepatic portosystemic shunt stent grafts be underdilated?. J Vasc Interv Radiol 2015; 26 (03) 382-387
  • 38 Pieper CC, Sprinkart AM, Nadal J. , et al. Postinterventional passive expansion of partially dilated transjugular intrahepatic portosystemic shunt stents. J Vasc Interv Radiol 2015; 26 (03) 388-394
  • 39 Pieper CC, Jansen C, Meyer C. , et al. Prospective evaluation of passive expansion of partially dilated transjugular intrahepatic portosystemic shunt stent grafts-a three-dimensional sonography study. J Vasc Interv Radiol 2017; 28 (01) 117-125
  • 40 Monescillo A, Martínez-Lagares F, Ruiz-del-Arbol L. , et al. Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology 2004; 40 (04) 793-801
  • 41 García-Pagán JC, Caca K, Bureau C. , et al; Early TIPS (Transjugular Intrahepatic Portosystemic Shunt) Cooperative Study Group. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010; 362 (25) 2370-2379
  • 42 Garcia-Pagán JC, Di Pascoli M, Caca K. , et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. J Hepatol 2013; 58 (01) 45-50
  • 43 Holster IL, Tjwa ET, Moelker A. , et al. Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy + β-blocker for prevention of variceal rebleeding. Hepatology 2016; 63 (02) 581-589
  • 44 Qi X, Jia J, Bai M. , et al. Transjugular intrahepatic portosystemic shunt for acute variceal bleeding: a meta-analysis. J Clin Gastroenterol 2015; 49 (06) 495-505
  • 45 Deltenre P, Trépo E, Rudler M. , et al. Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials. Eur J Gastroenterol Hepatol 2015; 27 (09) e1-e9
  • 46 de Franchis R. ; Baveno VI Faculty. Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol 2015; 63 (03) 743-752
  • 47 Qi X, Liu L, Bai M. , et al. Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol 2014; 29 (04) 688-696
  • 48 Procaccini NJ, Al-Osaimi AM, Northup P, Argo C, Caldwell SH. Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis. Gastrointest Endosc 2009; 70 (05) 881-887
  • 49 Lo GH, Liang HL, Chen WC. , et al. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy 2007; 39 (08) 679-685
  • 50 Mahadeva S, Bellamy MC, Kessel D, Davies MH, Millson CE. Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding. Am J Gastroenterol 2003; 98 (12) 2688-2693
  • 51 Barange K, Péron JM, Imani K. , et al. Transjugular intrahepatic portosystemic shunt in the treatment of refractory bleeding from ruptured gastric varices. Hepatology 1999; 30 (05) 1139-1143
  • 52 Spahr L, Dufresne MP, Bui BT. , et al. Efficacy of TIPS in the prevention of rebleeding from esophageal and fundal varices: a comparative study. Hepatology 1995; 22: 296A
  • 53 Saad WE. Vascular anatomy and the morphologic and hemodynamic classifications of gastric varices and spontaneous portosystemic shunts relevant to the BRTO procedure. Tech Vasc Interv Radiol 2013; 16 (02) 60-100
  • 54 Saad WE, Darcy MD. Transjugular intrahepatic portosystemic shunt (TIPS) versus Balloon-occluded retrograde transvenous obliteration (BRTO) for the management of gastric varices. Semin Intervent Radiol 2011; 28 (03) 339-349
  • 55 Sanyal AJ, Freedman AM, Luketic VA. , et al. The natural history of portal hypertension after transjugular intrahepatic portosystemic shunts. Gastroenterology 1997; 112 (03) 889-898
  • 56 Chao Y, Lin HC, Lee FY. , et al. Hepatic hemodynamic features in patients with esophageal or gastric varices. J Hepatol 1993; 19 (01) 85-89
  • 57 Lakhoo J, Bui JT, Lokken RP, Ray Jr CE, Gaba RC. Transjugular intrahepatic portosystemic shunt creation and variceal coil or plug embolization ineffectively attain gastric variceal decompression or occlusion: results of a 26-patient retrospective study. J Vasc Interv Radiol 2016; 27 (07) 1001-1011
  • 58 Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. ; Practice Guidelines Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46 (03) 922-938
  • 59 Saad WE, Wagner CC, Lippert A. , et al. Protective value of TIPS against the development of hydrothorax/ascites and upper gastrointestinal bleeding after balloon-occluded retrograde transvenous obliteration (BRTO). Am J Gastroenterol 2013; 108 (10) 1612-1619
  • 60 Saad WE, Brown DB, Schenning R. , et al. Clinical outcomes of BRTO only versus BRTO and TIPS for the management of gastric variceal bleeding: a multicenter USA study. J Vasc Interv Radiol 2013; 24: S63-S64
  • 61 LaBerge JM, Somberg KA, Lake JR. , et al. Two-year outcome following transjugular intrahepatic portosystemic shunt for variceal bleeding: results in 90 patients. Gastroenterology 1995; 108 (04) 1143-1151
  • 62 Sahagun G, Benner KG, Saxon R. , et al. Outcome of 100 patients after transjugular intrahepatic portosystemic shunt for variceal hemorrhage. Am J Gastroenterol 1997; 92 (09) 1444-1452
  • 63 Casado M, Bosch J, García-Pagán JC. , et al. Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings. Gastroenterology 1998; 114 (06) 1296-1303
  • 64 Chau TN, Patch D, Chan YW, Nagral A, Dick R, Burroughs AK. “Salvage” transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Gastroenterology 1998; 114 (05) 981-987
  • 65 Bañares R, Casado M, Rodríguez-Láiz JM. , et al. Urgent transjugular intrahepatic portosystemic shunt for control of acute variceal bleeding. Am J Gastroenterol 1998; 93 (01) 75-79
  • 66 Charon JP, Alaeddin FH, Pimpalwar SA. , et al. Results of a retrospective multicenter trial of the Viatorr expanded polytetrafluoroethylene-covered stent-graft for transjugular intrahepatic portosystemic shunt creation. J Vasc Interv Radiol 2004; 15 (11) 1219-1230
  • 67 Tripathi D, Ferguson J, Barkell H. , et al. Improved clinical outcome with transjugular intrahepatic portosystemic stent-shunt utilizing polytetrafluoroethylene-covered stents. Eur J Gastroenterol Hepatol 2006; 18 (03) 225-232
  • 68 Sauerbruch T, Mengel M, Dollinger M. , et al; German Study Group for Prophylaxis of Variceal Rebleeding. Prevention of rebleeding from esophageal varices in patients with cirrhosis receiving small-diameter stents versus hemodynamically controlled medical therapy. Gastroenterology 2015; 149 (03) 660-8.e1
  • 69 Lakhoo J, Bui JT, Zivin SP. , et al. Root cause analysis of rebleeding events following transjugular intrahepatic portosystemic shunt creation for variceal hemorrhage. J Vasc Interv Radiol 2015; 26 (10) 1444-1453
  • 70 Tesdal IK, Filser T, Weiss C, Holm E, Dueber C, Jaschke W. Transjugular intrahepatic portosystemic shunts: adjunctive embolotherapy of gastroesophageal collateral vessels in the prevention of variceal rebleeding. Radiology 2005; 236 (01) 360-367
  • 71 Wu XJ, Cao JM, Han JM, Li JS. Long-term results of TIPS, TIPS with CVO and combined TIPS and portal azygous disconnection for the treatment of portal hypertension [in Chinese]. Zhonghua Wai Ke Za Zhi 2009; 47 (06) 446-449
  • 72 Gaba RC, Bui JT, Cotler SJ. , et al. Rebleeding rates following TIPS for variceal hemorrhage in the Viatorr era: TIPS alone versus TIPS with variceal embolization. Hepatol Int 2010; 4 (04) 749-756
  • 73 Xue H, Yuan J, Chao-Li Y. , et al. Follow-up study of transjugular intrahepatic portosystemic shunt in the treatment of portal hypertension. Dig Dis Sci 2011; 56 (11) 3350-3356
  • 74 Xiao T, Chen L, Chen W. , et al. Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone versus TIPS combined with embolotherapy in advanced cirrhosis: a retrospective study. J Clin Gastroenterol 2011; 45 (07) 643-650
  • 75 Wei B, Chen S, Li X, Tang CW. Prevention of variceal rebleeding by TIPS combined with embolization of gastric coronary veins: a clinical controlled study [in Chinese]. Zhonghua Gan Zang Bing Za Zhi 2011; 19 (07) 494-497
  • 76 Chen S, Li X, Wei B. , et al. Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 2013; 268 (03) 900-906
  • 77 Shi Y, Tian X, Hu J. , et al. Efficacy of transjugular intrahepatic portosystemic shunt with adjunctive embolotherapy with cyanoacrylate for esophageal variceal bleeding. Dig Dis Sci 2014; 59 (09) 2325-2332