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DOI: 10.1055/s-0038-1629830
Evaluation of Pentavalent Tc-99m DMSA Scintigraphy in Small Cell and Nonsmall Cell Lung Cancers
99mTc-(V) DMSA-Szintigraphie beim kleinzelligen und nichtkleinzelligen BronchialkarzinomPublication History
Received:
26 November 1996
in revised form:
25 February 1997
Publication Date:
03 February 2018 (online)
Summary
Aim: The purpose of this study was to evaluate the clinical usefulness of Tc-99m (V) DMSA in patients suspected of lung cancer and determine whether this agent may have value in differentiation between small cell (SCLC) and non-small cell (NSCLC) lung carcinoma. Methods: Thirty-six patients with clinical and radiological suspicion of primary lung carcinoma were injected 450-600 MBq of Tc-99m (V) DMSA intravenously. Whole body and planar anterior, posterior thorax images were obtained 4-5 h after injection of the radioactive complex. Results: Histo-pathological results confirmed 23 NSCLC, 10 SCLC and 1 metastatic lung carcinoma and 2 lung abscess. Nineteen of the 23 (82%) NSCLC and all of the 10 (100%) SCLC cases showed Tc-99m (V) DMSA uptake. Single metastatic lung cancer also accumulated radiotracer. Lung abscess did not show uptake. Lesion/Nonlesion (L/N) ratio of SCLC (1.59 ± 0.32) and NSCLC (1.43 ± 0.19) tumour types did not show statistical difference (p >0.05). Tc-99m (V) DMSA whole body imaging also showed bone metastases. Conclusion: Tc-99m (V) DMSA is a noninvasive and cheap imaging method to detect malignant lung cancers and their bone metastases but, differentiation of SCLC and NSCLC is not possible.
Zusammenfassung
Ziel: Prüfung der klinischen Brauchbarkeit von 99mTc-(V) DMSA bei Patienten mit Verdacht auf Bronchialkarzinom im Hinblick auf die Möglichkeit einer Differenzierung zwischen Kleinzeller (KLZ) und Nichtkleinzeller (NKLZ). Methoden: Bei 36 Patienten mit klinischem und radiologischem Hinweis auf Bronchialkarzinom wurden 450 bis 600 MBq 99mTc-(V) DMSA i.v. appliziert. 4-5 h später wurden Ganzkörper- und planare Szinti-gramme des Thorax durchgeführt. Ergebnisse: Feingewebliche Untersuchungen bestätigten in 23 Fällen NKLZ, zehnmal KLZ, einmal ein me-tastasierendes Bronchialkarzinom und zwei Lungenabszesse. 19 der 23 NKLZ- (82%) und 100% der KLZ-Fälle zeigten eine 99mTc-(V) DMSA-Speicherung ebenso wie das metastasierende Bronchialkarzinom. Die Abszesse speicherten nicht. Das Speicherverhältnis Tumor/Thoraxgegenseite betrug bei KLZ 1,59 ± 0,32, bei NKLZ 1,43 ± 0,19 und war nicht statistisch signifikant unterschiedlich. Die Ganzkörperszintigra-phien zeigten zusätzlich Knochenmetastasen. Schlußfolgerung: Die 99mTc-(V) DMSA-Szintigraphie ist eine nichtinvasive und preiswerte Methode, um Bronchialkarzinome und deren Knochenmetastasen nachzuweisen; eine Differenzierung von Kleinzellern und Nichtkleinzellern ist dagegen nicht möglich.
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