Clear-Cell Sarcoma of Tendons and Aponeuroses Studied by Immunoscintigraphy

Summary

Clear-cell sarcoma is a rare tumor that arises in association with tendons and aponeuroses. Although it shares with malignant melanoma several histologic and ultrastructural features, it has a clinical course different from that of conventional melanomas. A case of clear-cell sarcoma studied by immunoscintigraphy with ^99mTc-labeled F(ab’)2 fragments of the monoclonal antibody 225.28 S is reported.

Zusammenfassung

Das clear cell-Sarkom ist ein seltener Tumor, der von der Vereinigung von Sehnen und Aponeurosen stammt. Obwohl er mit dem malignen Melanom histologische und ultrastrukturelle Ähnlichkeiten aufweist, stimmt sein klinischer Verlauf mit jenem konventioneller Melanome nicht überein. Ein Fall eines clear cell-Sarkoms wurde mittels Immunszintigraphie mit ^99mTc-markierten monoklonalen Antikörper 225.28S F(ab’)2-Fragmenten diagnostiziert.

Keywords

Clear-cell sarcoma - malignant melanoma - immunoscintigraphy - F(ab’)2 MoAb 225.28S

Schlüsselwörter

Clear cell-Sarkom - malignes Melanom - Immunszintigraphie - F(ab’)2 MoAb 225.28S

• References

• 1 Buell U, Weiller G, Hofstadter F. Classification of a tumor in the popliteal fossa by radioimmunoscintigraphy 11 years after resection of a malignant melanoma. Int J Biol Markers 1986; 1 (Suppl. 03) 155-8.
• 2 Eckart JJ, Pritchard DJ, Soule EH. Clear cell sarcoma. A clinicopathologic study of 27 cases. Cancer 1983; 52: 1482-8.
• 3 Enzinger FM, Weiss SW. Malignant tumors of uncertain histogenesis. In: Soft tissue tumors, the C. V. Mosby Company, 2nd Ed. St. Louis: 1988: 929-65.
• 4 Epstein AL, Martin AO, Kempson R. Use of a newly established human line (SU-CCS-1) to demonstrate the relationship of clear cell sarcoma to malignant melanoma. Cancer Res 1984; 44: 1265-74.
• 5 Mechtersheimer G, Tilgen W, Klar E, Moller P. Clear cell sarcoma of tendons and aponeuroses: case presentation with special reference to immunohistochemical findings. Hum Pathol 1989; 20 (Suppl. 09) 914-7.
• 6 Mii Y, Miyauchi Y, Huhnoki K. et al. Neural crest origin of clear cell sarcoma of tendons and aponeuroses. Ultrastructural and enzyme cytochemical study of human and nude mousetransplanted tumors. Virchows Arch Allg Pathol Anat Histopathol 1989; 415 (Suppl. 01) 51-60.
• 7 Natali PG, Giacomini P, Buraggi G. et al. Serological and binding characteristics of a monoclonal antibody (MoAb) to a human high molecular weight-melanoma associated antigen (HMW-MAA) for tumor imaging. In: From oncogenesis to tumor antigens. Giraldo G, Beth E, Castello G, Giordano GG, Zarilli D. (eds). Amsterdam: Elsevier Publ; 1984: 127-34.
• 8 Siccardi AG, Buraggi GL, Callegaro L. et al. Multicenter study of immunoscintigraphy with radiolabeled monoclonal antibodies in patients with melanoma. Cancer Res 1986; 46: 4817-22.
• 9 Siccardi AG, Buraggi GL, Natali PG. et al. European multicenter study on melanoma immunoscintigraphy by means of ^99mTc-labelled monoclonal antibody fragments. Eur J Nucl Med 1990; 16: 317-23.
• 10 Steger GG, Wrba F, Macher R. et al. Complete remission of metastasized clear cell sarcoma of tendons and aponeuroses. Eur J Cancer 1991; 27 (Suppl. 03) 254-6.
• 11 Swanson PE, Wick MR. Clear cell sarcoma. An immunohistochemical analysis of six cases and comparison with other epithelioid neoplasms of soft tissue. Arch Pathol Lab Med 1989; 113,1: 55-60.
• 12 Vieira MR, Rodrigues M, Nogueira A. et al. Imaging of malignant melanoma with tech-netium-99m labelled monoclonal antibodies. Rev Oncol 1992; 3: 55-7.