^99mTc-Labelled Anti NCA-95 Antibodies in Prosthetic Heart Valve Endocarditis

A 54-y old women with earlier replacement of the mitral and aortic valves and clinical signs of localized endocarditis was studied with ^99mTc-labelled anti NCA-95 antibody. Whereas echocardiographic findings were negative, increased radionuclide uptake was observed left parasternal over the mitral valve as a sign of prosthetic valve endocarditis. This result could be confirmed by a similar study with leukocytes labelled in vitro with ¹¹¹ln-oxine.

Zusammenfassung

Bei einer 54jährigen Patientin mit klinischen Zeichen der Sepsis bei bekanntem Ersatz der Mitral- und Aortenklappen konnte die Mitralklappe als Fokus mittels monoklonaler ^99mTc-markierter Anti-NCA-95-Antikörper erkannt werden. Der Befund konnte durch die Verwendung von Leukozyten, die mit ¹¹¹In-Oxin markiert waren, bestätigt werden.

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