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DOI: 10.1055/s-0038-1629351
Husten und Asthma bronchiale
Cough and asthmaPublication History
Eingereicht am:18 June 2013
angenommen am:09 July 2013
Publication Date:
31 January 2018 (online)

Zusammenfassung
Das Asthma bronchiale ist die häufigste chronische Erkrankung im Kindesalter, ca. 10 % der Kinder sind im Schulalter betroffen. Je nach Alter und Schweregrad können die klinischen Symptome deutlich variieren. Der charakteristische Husten tritt vor allem bei Infekten der oberen Atemwege, aber auch bei körperlicher Anstrengung und bei allergischen Asthmatikern, abhängig von der Allergenex-position, auf. Gräser- oder Pollenallergiker leiden vor allem an saisonalen Beschwerden in Kombination mit einer allergischen Rhinitis, während die Beschwerden derer, die von perennialen Allergenen wie Hausstaubmilben oder Tierhaaren betroffen sind, unspezifisch über das ganze Jahr verteilt sind. Im Säuglings- bzw. Kleinkindesalter gilt besondere Vorsicht bei der Diagnosestellung Asthma, da es zahlreiche Differenzialdiagnosen zu berücksichtigen gibt. Auch haben viele dieser Kinder transient auftretende viral getriggerte rezidivierende obstruktive Bronchi-tiden, die nicht in ein chronisches Asthma übergehen. Da in diesem Alter jedoch noch kein Lungenfunktionstest durchgeführt werden kann, muss die Diagnose anhand des klinischen Verlaufes, dem Vorhandensein von Risikofaktoren und dem Ansprechen auf eine spezifische Therapie gestellt werden.
Summary
Asthma is the most common chronic childhood disease, about 10 % of school-aged children are affected. Depending on age and severity symptoms can be very different. Characteristic coughing occurs primarily during physical activity and infections of the upper respiratory tract meanwhile in allergic children with asthma it depends on the allergen: kids with seasonal allergies (e. g. grass, pollen) suffer mainly of seasonal symptoms in combination with allergic rhinitis, while the complaints of those who are affected by perennial allergens such as house dust mites or animals, are distributed non-specifically throughout the year. In infancy particular care is needed to diagnose asthma because of many other possible diseases: clinically these children have often virally triggered recurrent obstructive bronchitis without ever developing asthma. Since lung function tests cannot be performed in this age group easily, the diagnosis must be based on the clinical course, the presence of risk factors and response to specific therapy.
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Literatur
- 1 AWMF. Nationale Versorgungs Leitlinie Asthma. Kurzfassung, 2. Aufl. Version 1.2 November 2010 www.asthma.versorgungsleitlinien.de
- 2 Bacharier L. et al. Diagnosis and management of early asthma in preschool-aged children. J Allergy Clin Immunol 2012; 130: 287-296.
- 3 Bacharier LB, Phillips BR, Bloomberg GR. et al. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immunol 2007; 119: 604-610.
- 4 Bisgaard H, Zielen S, Garcia-Garcia ML. et al. Montelukast reduces asthma exacerbations in 2- to 5- year- old children with intermittent asthma. Am J Respir Crit Care Med 2005; 171: 315-322.
- 5 Brand PL, Baraldi E, Bisgaard H. et al. Definition, assessment, and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32: 1096-1110.
- 6 Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162: 1403-1406.
- 7 Ducharme FM, Lemire C, Nova FJ. et al. Randomized controlledtrial of intermittend high dose fluticasone versus placebo in young children with viral-induced asthma. Am J Resp Crit Care Med 2007; 175 (Suppl. 01) A958
- 8 Duiverman EJ, Brackel HJ, Merkus PJ. et al. (Guideline „Treating asthma in children“ for pediatric pulmonologists (2nd revised edition). II. Medical treatment. Ned Tijdschr Geneeskd 2003; 147: 1909-1913.
- 9 Even L, Heno N, Talmon Y. et al. Diagnostic evaluation of foreign body aspiration in children: a prospective study. J Pediatr Surg 2005; 40: 1122-1127.
- 10 Frey U, von Mutius E. The challenge of managing wheezing in infants. N Engl J Med 2009; 360: 2130-2133.
- 11 Harding SM. Gastroesophageal reflux and asthma: insight into the association. J Allergy Clin Immunol 1999; 104: 251-259.
- 12 lli S, von Mutius E, Lau S. et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368: 763-770.
- 13 Martinez FD, Wright AL, Taussig LM. et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332: 133-138.
- 14 Morgan WJ, Stern DA, Sherill DL. et al. Outcome of asthma and wheezing in the first 6 years of life: follow up through adolescence. Am J Respir Crit Care Med 2005; 172: 1253-1258.
- 15 Nickel R, Kulig M, Forster J. et al. Sensitization to hens egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997; 99: 613-617.
- 16 Patra S, Singh VChandra. et al. Diagnostic modalities for gastroesophageal reflux in infantile wheezers. J Trop Pediatr 2011; 57: 99-103.
- 17 Sears MR, Greene JM, Willan AR. et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349: 1414-1422.
- 18 Sheikh S, Stephen T, Howell L, Eid N. Gastroesophageal reflux in infants with wheezing. Pediatr Pulmonol 1999; 28: 181-186.
- 19 Stein RT, Sherrill D, Morgan WJ. et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541-545.
- 20 Szefler SJ, Baker JW, Uryniak T. et al. Comparative study of budesonide inhalation suspension and montelukast in young children with mild persistent asthma. J Allergy Clin Immunol 2007; 120: 1043-1050.
- 21 Taussig LM, Wright AL, Holberg CJ. et al. Tuscon Children´s respiratory Study: 1980 to present. J Allergy Clin Immunol 2003; 111: 661-675.
- 22 Zeiger R. et al. Daily or Intermittent Budesonide in Preschool Children with Recurrent Wheezing. N Engl J Med 2011; 365: 1990-2001.
- 23 Zöllner I. et al. No increase in the prevalence of asthma, allergies, and atopic sensitisation among children in Germany: 1992-2001. Thorax 2005; 60: 545-548.