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Nuklearmedizin 1987; 26(03): 131-134
DOI: 10.1055/s-0038-1628876
Review Articles
Schattauer GmbH

Biodistribution of N-lsopropyl-p-lodoamphetamine in the Rat Brain

H. Hoshi
1   From the Department of Radiology, Miyazaki Medical College, Miyazaki, Japan
,
S. Jinnouchi
1   From the Department of Radiology, Miyazaki Medical College, Miyazaki, Japan
,
K. Watanabe
1   From the Department of Radiology, Miyazaki Medical College, Miyazaki, Japan
,
T. Ueda
2   The Department of Neurosurgery, Miyazaki Medical College, Miyazaki, Japan
,
K. Kinoshita
2   The Department of Neurosurgery, Miyazaki Medical College, Miyazaki, Japan
,
T. Yamaguchi
3   The Department of Hygiene, Miyazaki Medical College, Miyazaki, Japan
› Author Affiliations
Further Information

Publication History

Received: 02 December 1986

in revised form: 18 February 1987

Publication Date:
04 February 2018 (online)

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The biodistribution of N-isopropyl-p-iodoamphetamine (IMP) was studied in the rat brain.131 l-labelled IMP was injected intravenously in awake animals. Activities in the brain of Sprague-Dawley rats were 2.68–3.22 (% dose/g) in the cortex and 0.59–0.66 (% dose/g) in the white matter at 1 min p. i. Activities in the cortex were slightly increased at 60 min p. i., while activities in the white matter increased markedly at 60 min and 6 h p. i. Therefore, the cerebral cortex-to-white matter ratio decreased from 5 to 1 within 60 min after injection. Autoradiograms of the rat brain at 1–10 min p. i. showed high contrasts. Activities were high in the cortex and low in the white matter, but homogeneous at 60 min – 6 h. IMP seems to be a useful agent for cerebral perfusion imaging in the early phase after injection. Knowledge of biodistribution of this agent is considered to be indispensable for the interpretation of images.

Zusammenfassung

Die Bioverteilung von N-Isopropyl-p-Jodamphetamin (IMP) wurde im Gehirn der Ratte untersucht. 131J-markiertes IMP wurde nichtanästhesierten Sprague-Dawley Tieren i. v. injiziert. Die Aktivitätskonzentration im Gehirn betrug 1 Min. nach der Injektion 2,68–3,20% injizierter Aktivität/g im Cortex und 0,59–0,66% injizierter Aktivität/g in der weißen Substanz. Bis zu 60 Min. p. i. stieg die Aktivität im Cortex leicht an. Die Konzentrationen in der weißen Substanz nahmen dagegen zwischen 60 Min. und 6 h p. i. deutlicher zu. Somit verminderte sich zwischen 1 und 60 Min. p. i. das Speicherverhältnis Cortex – weiße Substanz von 5 auf 1. Autoradiogramme des Rattenhirns zum Zeitpunkt 1 bis 10 Min. p. i. zeigten hohe Aktivitätskontraste. Hohe Ruheaktivitäten fanden sich im Cortex, niedrige in der weißen Substanz. 60 Min. bis 6 h p. i. war die Verteilung deutlich homogener. IMP erwies sich unmittelbar nach der Injektion als brauchbare Substanz zur Darstellung der Hirndurchblutung. Kenntnisse über die Bioverteilung dieser Substanz sind für die Interpretation der Befunde unabdingbar.

 

  • REFERENCES

  • 1 Carlsen L, Anderson K. 131I-label- led N-isopropyl-p-iodoamphetamine. Eur. J. nucl. Med 1982; 07: 280-1.
    Google Scholar
  • 2 Goldman S. S, Hass W. K, Ransohoff J. Unsymmetrical alkyl aryl thiurea compounds for use as cerebral blood flow tracers. Amer. J. Physiol 1980; 238: 776-87.
    Google Scholar
  • 3 Holman B. L, Hill T. C, Lee R. G. L. et al. Brain imaging with radiolabeled amines. In: Nuclear Medicine Annual 1983. Freeman L. M, Wissmann H. S. (eds.) 131-65. Raven Press; New York: 1983
    Google Scholar
  • 4 Knust E. J, Machulla H. J, Baldwin R. M, Chen T. Synthesis of, and animal experiments with N-isopropyl-p- 123l iodoamphetamine (IMP) and F-18 3- deoxy-3-fuluoro-D-glucose (3-FDG) as tracers in brain and heart diagnostic studies. Nucl.-Med 1984; 23: 31-4.
    Google Scholar
  • 5 Lassen N. A, Henriksen L, Holm S. et al Cerebral blood flow tomography: Xenon-133 compared with isopropylampheta- mine-iodine-123. J. nucl. Med 1983; 24: 17-21.
    PubMedGoogle Scholar
  • 6 Momose T, Kosaka N, Nisikawa J. et al. Crossed cerebellar diaschisis in cerebrovascular disease detected by N-isopro- pyl 123I iodoamphetamine (123I-IMP) with SPECT. Jpn. J. nucl. Med 1986; 23: 25-34.
    Google Scholar
  • 7 Rahimian J, Glass E. C, Touya J. et al. Measurement of metabolic extraction of tracers in the lung using a multiple indicator dilution technique. J. nucl. Med 1984; 25: 31-7.
    PubMedGoogle Scholar
  • 8 Rapin J. R, Poncin-Laffite M, Duterte D. et al. Radiopharmacologic studies of isopropyl-iodoamphetamine. In: Nuclear Medicine Annual 1983. Freeman L. M, Wissmann H. S. (eds.) 209-16. Raven Press; New York: 1983
    Google Scholar
  • 9 Rapin J. R, Poncin-Lafitte M, Duterte D. et al. Iodoamphetamine as a new tracer for local cerebral blood flow in the rat: Comparison with isopropyliodoamphetamine. J. cereb. Blood Flow Metabol 1984; 04: 270-4.
    Google Scholar
  • 10 Sakurada O, Kennedy C, Jehle J. et al. Measurement of local cerebral blood flow with iodo 14C antipyrine. Amer. J. Physiol 1978; 234: 59-66.
    Google Scholar
  • 11 Winchell H. S, Baldwin R. M, Lin T. H. Development of 123I-labeled amines for brain studies: Localization of 123I iodo- phenylalkyl amines in rat brain. J. nucl. Med 1980; 21: 940-6.
    PubMedGoogle Scholar
  • 12 Winchell H. S, Horst W. D, Braun L. et al. N-isopropyl-[123I] p-iodoamphetamine: Single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain. J. nucl. Med 1980; 21: 947-52.
    PubMedGoogle Scholar