Nervenheilkunde 2013; 32(04): 192-196
DOI: 10.1055/s-0038-1628501
Autonomes Nervensystem
Schattauer GmbH

Dysautonomias in amyloidosis

Need for an interdisciplinary approach Article in several languages: English | deutsch
B. P. C. Hazenberg
1   Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands
› Author Affiliations
Further Information

Publication History

eingegangen am: 26 October 2012

angenommen am: 29 October 2012

Publication Date:
24 January 2018 (online)

Summary

Systemic amyloidosis is a life-threatening and frequently unrecognized cause of dysautonomia. Autonomic neuropathy is a common manifestation of AL amyloidosis (caused by deposition of an immunoglobulin free light chain produced by an underlying plasma cell clone) and of autosomal dominant hereditary ATTR amyloidosis (caused by a transthyretin mutation). The following review aims to alert clinicians to look out for signs and symptoms of amyloidosis to enable the bioptic diagnosis at an early stage. Suspicion of systemic amyloidosis is usually raised by the systemic, multi-organ character of the disease. An interdisciplinary approach is needed in the individual patient in order to establish the diagnosis and to obtain a clear overview of the actual multitude of organ problems. This overview is necessary for risk management and for making a well-considered treatment choice. Collaboration of all medical specialists involved is necessary to deliver optimal treatment and care to the patient with this systemic disease.