Positronen-Emissions-Tomografie bei Substanzmissbrauch und Sucht

Zusammenfassung

Die neurofunktionelle Bildgebung mittels Positronen- Emissions-Tomografie (PET) hat in den letzten zwei Dekaden einen maßgeblichen Beitrag zur Erforschung der neurobiologischen Grundlagen von Substanzmissbrauch und Abhängigkeit geleistet. So ist es möglich, neben der Identifikation wichtiger Netzwerkstrukturen (z. B. Belohnungssystem und frontolimbische Schleifen) auch die beteiligten Neurotransmittersysteme (z. B. mesolimbische dopaminerge Projektionen) experimentell in vivo zu untersuchen. Derzeit wird die PET zunehmend in der Therapieforschung zur biologischen Evaluation potenzieller „Anti- Craving“-Substanzen eingesetzt. Der vorliegende Artikel gibt einen kurzgefassten Überblick über den aktuellen Stand der PET-Forschung bei Substanzmissbrauch und Abhängigkeitserkrankungen.

Summary

In the last two decades functional neuroimaging by means of PET could considerably contribute to neurobiological research in substance abuse and addiction. In vivo functional neuroimaging allows identifying the relevant network structures (i. e. reward system and fronto-limbic loops) as well as investigating the underlying transmitter systems (i. e. mesolimbic dopaminergic projections). For the last years, PET also gains increasing relevance in therapy research in order to evaluate potential “anti-craving” drugs on a biological basis. This article gives a short survey on the current state of PET research in substance abuse and addiction.

Schlüsselwörter

PET - Metabolismus - Liganden - Sucht - Drogen

Keywords

PET - metabolism - ligand - addiction - drugs

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