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Nuklearmedizin 2010; 49(S 01): S64-S68
DOI: 10.1055/s-0038-1626526
DOI: 10.1055/s-0038-1626526
Übersichtsarbeit
Bestimmung der DNA-Schädigung in vitro
Artikel in mehreren Sprachen: deutsch | EnglishWeitere Informationen
Publikationsverlauf
Eingegangen:
12. Oktober 2010
angenommen:
13. Oktober 2010
Publikationsdatum:
24. Januar 2018 (online)
Zusammenfassung
Ionisierende Strahlen wirken primär über die Erzeugung von DNA-Schäden, worunter DNADoppelstrangbrüche die wichtigsten Läsionen sind. Aus diesen Schäden können sich letale Chromosomenaberrationen entwickeln, die im Wesentlichen für die Zellinaktivierung verantwortlich sind. Doppelstrangbrüche können über verschiedene Mechanismen repariert werden, deren Regulation zwischen Normalund Tumorzellen erheblich variieren kann. Die Kapazität der Doppelstrangbruchreparatur ist vor allem genetisch determiniert und variiert nur um wenige Prozente. Kenntnisse über die Mechanismen der Doppelstrangbruchreparatur und deren Regulation sind eine wichtige Voraussetzung für die optimale Anwendung der ionisierenden Strahlen in der Medizin.
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