Obesitas-Hypoventilationssyndrom

ADNAN MAAROUF; GEORG NILIUS

doi:10.1055/s-0038-1626177

Schlaf, Table of Contents

Schlaf 2017; 06(03): 126-131
DOI: 10.1055/s-0038-1626177

Review

Schattauer GmbH

Obesitas-Hypoventilationssyndrom

Authors

ADNAN MAAROUF

¹Klinikum Dortmund
GEORG NILIUS

²HELIOS Klinik Hagen-Ambrock, Email: georg.nilius@helios-kliniken.de

Abstract

Bei zunehmender Adipositas finden sich erheblich höhere Prävalenzen von obstruktiver Schlafapnoe und Hypoventilationssyndromen. Die internationalen Empfehlungen definieren das Obesitas-Hypoventilationssyndrom (OHS) bei Patienten mit einem BMI >30kg/m², die eine Hyperkapnie am Tage (PaCO₂ >45 mmHg) aufweisen, ohne dass diese durch andere Erkrankungen (wie z.B. eine COPD oder neuromuskuläre Erkrankungen) zu erklären ist.

Full Text

References

Literatur
1 Roberto CA, Swinburn B, Hawkes C. et al. Patchy progress on obesity prevention: emerging examples, entrenched barriers, and new thinking. Lancet 2015; 385: 2400-2409.
2 The GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017; 377: 13-27.
3 Mokhlesi B. Obesity hypoventilation syndrome: a state-of-the-art review. Respir Care 2010; 55 (10) 1347-1362.
4 Hart N, Mandal S, Manuel A. et al. Obesity hypoventilation syndrome (OHS): does the current definition need revisiting?. Thorax 2014; 69 (10) 955.
5 Mokhlesi B, Tulaimat A, Faibussowitsch I. et al. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath 2007; 11: 117-124.
6 Rapoport DM, Garay SM, Epstein H, Goldring RM. Hypercapnia in the obstructive sleep apnea syndrome: a reevaluation of the Pickwickian syndrome. Chest 1986; 89 (05) 627-635.
7 Javaheri S, Simbartl LA. Respiratory determinants of diurnal hypercapnia in obesity hypoventilation syndrome. What does weight have to do with it?. Ann Am Thorac Soc 2014; 11 (06) 945-950.
8 Piper AJ, Grunstein RR. Obesity hypoventilation syndrome: mechanisms and management. Am J Respir Crit Care Med 2011; 183 (03) 292-298.
9 Shimura R, Tatsumi K, Nakamura A. et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apneahypopnea syndrome. Chest 2005; 127: 543-549.
10 Berger KI, Ayappa I, Sorkin IB. et al. CO2 homeostasis during periodic breathing in obstructive sleep apnea. J Appl Physiol 2000; 88 (01) 257-264.
11 Hida W. Quality of life in obesity hypoventilation syndrome. Sleep Breath 2003; 7 (01) 1-2.
12 Berg G, Delaive K, Manfreda J, Walld R, Kryger MH. The use of health-care resources in obesity-hypoventilation syndrome. Chest 2001; 120 (02) 377-383.
13 Nowbar S, Burkart KM, Gonzales R. et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med 2004; 116: 1-7.
14 Murphy PB, Davidson C, Hind MD. et al. Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial. Thorax 2012; 67 (08) 727-734.
15 Weiner P, Waizman J, Weiner M. et al. Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance. Thorax 1998; 53: 39-42.
16 Masa JF, Corral J, Caballero C. et al. Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea. Thorax 2016; 71 (10) 899-906.
17 Windisch W, Brambring J, Budweiser S. et al. Projektgruppe Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen Insuffizienz. Pneumologie 2010; 64 (04) 207-240.
18 Budweiser S, Riedl SG, Jorres RA. et al. Mortality and prognostic factors in patients with obesity-hypoventilation syndrome undergoing non-invasive ventilation. J Intern Med 2007; 261: 375-383.
19 Piper A. Obesity Hypoventilation Syndrome: Weighing in on Therapy Options. Chest 2016; 149 (03) 856-868.