Abstract
Objectives While being overweight (body mass index [BMI] >25) prior to pregnancy is linked to
antenatal depression, whether weight is confounded by socioeconomic and/or medical
risks is unclear.
Study Design We assessed 66 healthy privately insured pregnant women at M = 35.0 ± 3.3 weeks for
symptoms of depression (Inventory for Depressive Symptoms—Self-Report (IDS-SR 30),
lifetime history of depression and other psychiatric conditions (Mini International
Neuropsychiatric Interview), and pre-pregnancy BMI derived from pre-pregnancy weight
(by recall) and directly measured height. Pre-pregnancy overweight (BMI > 25) and
antenatal depression (score of mild or greater [14] on the IDS-SR 30) were assessed
using logistic regression, controlling for past major depressive disorder (MDD) and
demographic factors showing significant between group differences.
Results Pre-pregnancy overweight (n = 17; 25.8%) was associated with an increased risk of third trimester depression,
independent of past MDD and marital status (odds ratio = 7.47; 95% confidence interval
[2.09–26.68]; B (standard error) = 2.010 [0.650]).
Conclusion Replication in a larger sample is suggested to confirm an independent effect of pregravid
overweight on third trimester depression.
Keywords
oxytocin - overweight - pregnancy - postpartum depression