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Nuklearmedizin 2005; 44(03): 76-80
DOI: 10.1055/s-0038-1625689
Original Articles
Schattauer GmbH

Direct injection of 188Re-microspheres in the treatment of hepatocellular carcinoma

Compared with traditional percutaneous ethanol injection: an animal studyDirekte Injektion von 188Re-Mikrosphären zur Behandlung des LeberzellkarzinomsVergleich mit traditioneller Ethanolinjektion – eine tierexperimentelle Studie
Y.-Ch. Lin
1   Department of Veterinary Medicine, National Chung-Hsing University, Taichung Departments of Nuclear Medicine
,
S.-Ch. Tsai
2   Show Chwan Memorial Hospital
,
G.-U. Hung
3   Changhua Christian Hospital, Changhua
,
J.-Ch. Lee
1   Department of Veterinary Medicine, National Chung-Hsing University, Taichung Departments of Nuclear Medicine
,
Y.-S. Huang
1   Department of Veterinary Medicine, National Chung-Hsing University, Taichung Departments of Nuclear Medicine
,
W.-Y. Lin
4   Taichung Veterans General Hospital, Taichung, Taiwan
› Author Affiliations
Further Information

Publication History

Received: 01 April 2004

in revised form: 30 September 2004

Publication Date:
10 January 2018 (online)

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Summary

The aim of this study was to compare the therapeutic efficacies of direct intratumoural injection of 188Re microspheres (DIRM) and direct intratumoural injection of ethanol (DIE) in rabbits bearing liver tumours. Materials and methods: Fifteen rabbits bearing liver tumours were divided into three groups: group 1 received DIE, group 2 received DIRM, and group 3 (control) received saline. Tumour size was measured by liver sonography before injection, as well as 2, 4, 8, and 12 weeks after injection. Survival time was calculated from the day of treatment to three months after treatment by Kaplan-Meier survival analysis. Results: The mean survival time was 68 ± 9.8 days for the rabbits in the DIRM group, 55.8 ± 11.8 days for the DIE group, and 38.8 ± 6.2 days for the control group. Conclusion: The rabbits survived longer in the DIRM group than in the DIE group although there is no statistical significance. We believe the DIRM method has a good potential to be an alternative to DIE for the treatment of liver tumours.

Zusammenfassung

Ziel der Studie war der Vergleich der therapeutischen Wirksamkeit der direkten intratumoralen Injektion von 188Re- Mikrosphären (DIRM) und der direkten intratumoralen Injektion von Ethanol (DIE) bei Kaninchen mit Lebertumoren. Materialien, Methoden: Fünfzehn Kaninchen mit Lebertumoren wurden drei Gruppen zugeordnet: Gruppe 1 erhielt DIE, Gruppe 2 DIRM und Gruppe 3 (Kontrolle) Kochsalzlösung. Die Tumorgröße wurde mittels Lebersonographie vor sowie 2, 4, 8 und 12 Wochen nach der Injektion gemessen. Die Überlebenszeit wurde anhand einer Kaplan-MeierÜberlebensanalyse vom Behandlungstag bis drei Monate nach der Behandlung errechnet. Ergebnisse: Die mittlere Überlebenszeit betrug bei den Kaninchen in der DIRMGruppe 68 ± 9,8 Tage, bei den Kaninchen in der DIEGruppe 55,8 ± 11,8 Tage und in der Kontrollgruppe 38,8 ± 6,2 Tage. Schlussfolgerung: Die Kaninchen in der DIRM-Gruppe überlebten länger als die Kaninchen in der DIE-Gruppe, wenngleich kein statistischer Unterschied besteht. Wir glauben, dass die DIRM-Methode ein gutes Potenzial als Alternative zur DIE für die Behandlung von Lebertumoren besitzt.

Keywords

Hepatocellular carcinoma - 188Re microspheres - ethanol injection

Schlüsselwörter

Leberzellkarzinom - 188Re-Mikrosphären - Ethanolinjektion
 

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