State-of-the-art of small animal imaging with high-resolution SPECT

Summary

During the recent years, in vivo imaging of small animals using SPECT has become of growing relevance. Along with the development of dedicated high-resolution small animal SPECT cameras, an increasing number of conventional clinical scanners has been equipped with single or multipinhole collimators. This paper reviews the small animal tomographs, which are operating at present and compares their performance characteristics. Furthermore, we describe the in vivo imaging studies, which have been performed so far with the individual scanners and survey current approaches to optimize molecular imaging with small animal SPECT.

Zusammenfassung

Die In-vivo-Bildgebung an Kleintieren mittels SPECT gewann in den vergangenen Jahren zunehmend an Bedeutung. Neben der Entwicklung dedizierter hochauflösender Kleintiertomographen wurden immer mehr konventionelle klinische Kameras mit Single- oder Multipinholekollimatoren aufgerüstet. In dieser Übersichtsarbeit werden die zurzeit eingesetzten Kleintier-SPECT-Systeme vorgestellt und hinsichtlich ihrer Performance verglichen. Ferner geben wir eine Übersicht über die bildgebenden Untersuchungen mit den einzelnen Kameras und schließen mit einem Überblick über gegenwärtige Ansätze zur Optimierung der molekularen Bildgebung mit Kleintier-SPECT.

Keywords

Small animal SPECT - pinhole SPECT - molecular imaging

Schlüsselwörter

Kleintier-SPECT - Pinhole-SPECT - molekulare Bildgebung

• Literatur

• 1 Acton PD, Choi SR, Plossl K. et al. Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography. Eur J Nucl Med Mol Imaging 2002; 29: 691-8.
• 2 Acton PD, Hou C, Kung MP. et al. Occupancy of dopamine D2 receptors in the mouse brain measured using ultra-high-resolution single-photon emission tomography and ¹²³IBF. Eur J Nucl Med Mol Imaging 2002; 29: 1507-15.
• 3 Beekman FJ, van der Have F, Vastenhouw B. et al. U-SPECT-I: A novel system for sub-mm resolution tomography of radiolabeled molecules in mice. J Nucl Med 2005; 46: 1194-200.
• 4 Booij J, de Bruin K, Habraken JB. et al. Imaging of dopamine transporters in rats using high-resolution pinhole single-photon emission tomography. Eur J Nucl Med Mol Imaging 2002; 29: 1221-4.
• 5 Chen L, Nohara R, Hirai T. et al. Effects of exercise training on myocardial fatty acid metabolism in rats with depressed cardiac function induced by transient ischemia. Jpn Circ J 2001; 65: 550-5.
• 6 Choong WS, Moses WW, Tindall CS. et al. Design for a high-resolution small-animal SPECT system using pixellated Si(Li) detectors for in vivo 125I imaging. IEEE Trans Nucl Sci 2003; NS-50: 1-6.
• 7 DelGuerra A, Damiani C, Di Domenico G. et al. An integrated PET-SPECT small animal overview: preliminary results. IEEE Trans Nucl Sci 2000; 47: 1537-40.
• 8 Di Domenico G, Giganti M, Motta A. et al. Quantitative PET-SPECT small animal scanner: preliminary results. IEEE NSS & MIC Conference Records 2001
• 9 Habraken JBA, de Bruin K, Shehata M. et al. Evaluation of a high-resolution pinhole SPECT using a small rotating animal. J Nucl Med 2001; 42: 1863-9.
• 10 Hirai T, Nohara R, Hosokawa R. et al. Evaluation of myocardial infarct size in rat heart by pinhole SPECT. J Nucl Cardiol 2000; 7: 107-11.
• 11 Hirai T, Nohara R, Ogoh S. et al. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. J Nucl Cardiol 2001; 8: 472-81.
• 12 Hoppin JW, Wirrwar A, Lackas C. et al. High-resolution multipinhole SPECT: initial human studies. Mol Imaging Biol 2005; 7: 123.
• 13 Ishizu K, Mukai T, Yonekura Y. et al. Ultra-high resolution SPECT system using four pinhole collimators for small animal studies. J Nucl Med 1995; 36: 2282-7.
• 14 Iwakura A, Fujita M, Kataoka K. et al. Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model. Heart Vessels 2003; 18: 93-9.
• 15 Jaszczak RJ, Li J, Wang H. et al. Pinhole collimation for ultra-high resolution, small-field-of-view SPECT. Phys Med Biol 1994; 39: 425-37.
• 16 Kastis GA, WU MC, Balzer SJ. et al. Tomographic small-animal imaging using a high-resolution semiconductor camera. IEEE NSS & MIC Conference Records 2000
• 17 Klein WP, Barrett HH, Pang IW. et al. FASTSPECT: Electrical and mechanical design of a high-resolution dynamic STECT imager. IEEE NSS & MIC Conference Records 1995
• 18 Liu Z, Kastis GA, Stevenson GD. et al. Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system. J Nucl Med 2002; 43: 933-9.
• 19 MacDonald LR, Patt BE, Iwanczyk JS. et al. Pinhole SPECT of mice using the LumaGEM gamma camera. IEEE Trans Nucl Sci 2001; 48: 830-6.
• 20 Mandl SJ, Mari C, Edinger M. et al. Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcome. Mol Imaging 2004; 3: 1-8.
• 21 Marsee DK, Shen DHY, MacDonald LR. et al. Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography. Cancer Gene Ther 2004; 11: 121-7.
• 22 Meikle SR, Wojcik R, Weisenberger AG. et al. CoALA-SPECT: a coded aperture laboratory animal SPECT system for pre clinical imaging. IEEE NSS & MIC Conference Records 2002
• 23 Nikolaus S, Wirrwar A, Antke C. et al. Blockade of the rat striatal dopamine transporter with methylphenidate – first in vivo investigations with ¹²³I-FPCIT and a dedicated small animal SPECT. Eur J Nucl Med Mol Imaging 2004; 32: 308-13.
• 24 Nikolaus S, Wirrwar A, Larisch R. et al. A landmark- based approach for the quantitation of receptor and transporter binding in the rat using small animal SPECT and PET. IEEE NSS & MIC Conference Records 2004
• 25 Nikolaus S, Larisch R, Wirrwar A. et al. Dopamin D2-Rezeptorverfügbarkeit in Striatum und Neokortex der Ratte – eine in vivo Kompetitionsstudie mit dem TierSPECT und Iod-123-IBZM . Nuklearmedizin 2005; 44: P47.
• 26 Ogawa K, Kawade T, Nakamura K. et al. Ultra high resolution pinhole SPECT for small animal study. IEEE Trans Nucl Sci 1998; 45: 3122-6.
• 27 Oh P, Li Y, Yu J. et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 2004; 429: 629-35.
• 28 Rowe RK, Aarsvold JN, Barrett HH. A stationary hemispherical SPECT imager for three-dimensional brain imaging. J Nucl Med 1993; 34: 474-80.
• 29 Saji H, Iida Y, Kawashima H. et al. In vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography. Anal Sci 2003; 19: 67-71.
• 30 Saoudi A, Valda Ochoa A, Mastrippolito R. et al. A minituarized high resolution gamma camera to image in vivo dopamine receptors in rat brain. In: Hermann HJ, Wolf DE, Pöppel E. (Hrsg). Supercompution in brain research: from tomography to neural networks. Singapore: World Scientific; 1995: 99-103.
• 31 Schäfers KP. Imaging small animals with positron emission tomography. Nuklearmedizin 2003; 42: 86-9.
• 32 Scherer A, Ostendorf B, Schramm NU. et al. Einsatz der Multipinhole-SPECT-Technik zur Messung entzündlicher Gelenkveränderungen im Arthritis- Maus-Modell . Nuklearmedizin 2005; 44: P395.
• 33 Scherfler C, Donnemiller E, Schocke M. et al. Evaluation of striatal dopamine transporter function in rats by in vivo beta-¹²³I-CIT pinhole SPECT. Neuroimage 2002; 17: 128-41.
• 34 Scherfler C, Scholz SW, Donnemiller E. et al. Evaluation of ¹²³I-IBZM pinhole SPECT for the detection of striatal dopamine D(2) receptor availability in rats. Neuroimage 2005; 24: 822-31.
• 35 Schramm N, Wirrwar A, Sonnenberg F. et al. Compact high resolution detector for small animal SPECT. IEEE Trans Nucl Sci 2000; 47: 1163-6.
• 36 Schramm NU, Ebel G, Engeland U. et al. High-resolution SPECT using multipinhole collimation. IEEE Trans Nucl Sci 2003; 50: 315-20.
• 37 Schurrat T, Alfke H, Behe M. et al. Molecular gastrin receptor localisation in mice using high-resolution SPET-MRI image fusion. Eur J Nucl Med Mol Imaging 2003; 30: 800.
• 38 Sohlberg A, Lensu S, Jolkkonen J. et al. Improving the quality of small animal brain pinhole SPECT imaging by Bayesian reconstruction. Eur J Nucl Med Mol Imaging 2004; 31: 986-94.
• 39 Strand SE, Ivanovic M, Erlandsson K. High resolution pinhole SPECT for tumor imaging. Acta Oncol 1993; 32: 861-7.
• 40 Taylor SJ, Barrett HH, Zinn KR. Small animal single photon emission computed tomography using a lens-coupled CCD camera. Mol Imaging Biol 2004; 6: 109.
• 41 Tuy HK. An inversion formula for cone-beam reconstruction. SIAM J Appl Math 1983; 43: 546-52.
• 42 Valda Ochoa A, Ploux L, Mastrippolito R. et al. An original emission tomograph for in vivo brain imaging of small animals. IEEE Trans Nucl Sci 1997; 44: 1533-7.
• 43 Wirrwar A, Arkian S, Nikolaus S. et al. First in vivo imaging of rats using a multipinhole collimator. Mol Imaging Biol 2004; 6: 91.
• 44 Wirrwar A, Nikolaus S, Nouné MY. et al. Dual- Isotope-Studien von Labortieren mit Multipinhole- SPECT: Eine neuartige nuklearmedizinische Methode zur gleichzeitigen Akquisition funktioneller und anatomischer Information . Nuklearmedizin 2005; 44: P62.
• 45 Wirrwar A, Schramm N, Nikolaus S. et al. Implementation of a multipinhole collimator for in vivo imaging of rats. IEEE NSS & MIC Conference Records 2003.
• 46 Wirrwar AK, Nikolaus S, Schramm NU. et al. Tier- SPECT: Leistungsparameter einer dedizierten Kleintier-SPECT-Kamera und erste in vivo Messungen. Z Med Phys 2005; 15: 14-22.
• 47 Wu MC, Da Silva AJ, Tang HR. et al. An ultra high resolution ECG-gated myocardial imaging system for small animals. IEEE Trans Nucl Sci 1999; 46: 1199-202.
• 48 Wu MC, Gao DW, Sievers RE. et al. Pinhole single- photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol 2003; 42: 576-82.
• 49 Wu MC, Tang HR, Gao DW. et al. ECG-gated Pinhole SPECT in mice with millimeter spatial resolution. IEEE Trans Nucl Sci 2000; 47: 1218-21.
• 50 www.gammamedica.com
• 51 Yokoi T, Kishi H. Development of a high-resolution pinhole SPECT system using dual-head gamma camera for small animal studies. Kaku Igaku 1998; 35: 901-7.
• 52 Yukihiro M, Inoue T, Iwasaki T. et al. Myocardial infarction in rats: high-resolution single-photon emission tomographic imaging with a pinhole collimator. Eur J Nucl Med 1996; 23: 896-900.
• 53 Zeniya T, Watabe H, Aoi T. et al. A new reconstruction strategy for image improvement in pinhole SPECT. Eur J Nucl Med Mol Imaging 2004; 1: 1166-72.