Absorbed Radiation Dose from Radionuclidic Impurities in Several ¹²³I-Labeled Radiopharmaceuticals

Summary

The radiation dose to patients from RISA, sodium iodohippurate, and rose bengal labeled with commercially available ¹²³I and its accompanying radio-impurities has been studied. The extra radiation dose to target organs was found to range from 29% to 97% that due to ¹²³I alone when the radiopharmaceutical is administered at calibration time. Additional delay in the time of administration increases the relative impurity dose.

Es wurde die Bestrahlungsdosis bei Patienten nach Gabe von RISA, Jodhippurat und Bengalrosa untersucht, welche mit dem handelsüblichen ¹²³J und dessen radioaktiven Verunreinigungen markiert waren. Die zusätzliche Strahlenbelastung der kritischen Organe wurde in einer Größenordnung von 29 bis 97 % gefunden gegenüber der alleinigen Belastung durch ¹²³J wenn die Anwendung auf die „calibration time” bezogen ist. Zusätzliche Verzögerungen bis zur Anwendungszeit lassen die relative Verunreinigungsdosis anwachsen.

^* Loyola University Stritch School of Medicine and Division of Nuclear Medicine, Michael Reese Hospital & Medical Center, Chicago, Ill.

^** Nuclear Medicine Service, Veterans Administration Hospital, Hines, Ill.

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