Comparison of Various Treatment Schedules for Accelerating the Elimination of Radioiodine from the Thyroid and the Human Body

Summary

In 68 euthyroid patients undergoing ¹³¹I thyroid function tests the thyroidal, urinary and plasma protein-bound radioactivity has been serially measured for 14 days. The patients were subdivided in controls and 9 groups treated with potassium iodide, Carbimazole, potassium Perchlorate and TSH, singly or in combination. The aim was to devise a treatment scheme for accelerating the release of iodine from the thyroid and the elimination from the body in cases of accidental radioiodine poisoning if the patient is seen after the radioiodine has already been taken up by the gland. All treatment schedules were effective, but TSH injections gave the best results, especially if combined with Carbimazole and potassium Perchlorate. This combination is the treatment of choice under these circumstances.

Bei 68 euthyreoten Patienten wurde nach Verabfolgung von ¹³¹J die Radioaktivität in der Schilddrüse, im Harn und in den Plasmaproteinen bestimmt. Die Patienten waren in 9 Gruppen, die eine Behandlung mit Kaliumjodid, Carbimazol, Kaliumperchlorat und Thyreotropin (TSH) einfach oder kombiniert erhielten und in die Kontrollgruppe geteilt. Unser Ziel war es, ein Behandlungs-schema zu finden das eine Beschleunigung der Ausscheidung von Jod aus der Schilddrüse und dem Körper im Falle einer Radiojodvergiftung hervorruft, wenn der Patient nach der Speicherung von Radiojod in der Schilddrüse zur Behandlung kommt. Alle Behandlungsschemata waren erfolgreich. Thyreotropin (TSH)-Injektionen geben die besten Ergebnisse, besonders wenn sie mit Carbimazol und Kaliumperchlorat kombiniert werden. Diese Kombination ist die Behandlung der Wahl unter diesen Bedingungen.

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