Biological and Chemical Investigations of 131I-Albumin Macroaggregates used for Lung Scintigraphy

I. Licińska; B. Lucka; B. Pszona; B. Sadowska; M. Wagner

doi:10.1055/s-0038-1624774

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1972; 11(01): 59-69
DOI: 10.1055/s-0038-1624774

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Biological and Chemical Investigations of ¹³¹I-Albumin Macroaggregates used for Lung Scintigraphy

Etudes biologiques et biochimiques des macroagrégats de l’albumine marqués avec le iode 131 employés dans la scintigraphic des poumonsBiologische und chemische Untersuchungen von ¹³¹J-Albumin-Makroaggregaten zur Lungenszintigraphie

Authors

I. Licińska^*

¹Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
B. Lucka^**

¹Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
B. Pszona^*

¹Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
B. Sadowska^**

¹Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
M. Wagner^**

¹Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw

Abstract

Summary

The parameters required to establish the usefulness of ¹³¹I-albumin macroaggregates for lung scintigraphy have been determined. The effects of successive washings, storage time, additional sterilization and of the quality of initial human serum albumin on radiochemical purity and biological behaviour of the product have been investigated.

On a établi des paramètres déterminant l’utilité des macroagrégats de l’albumine marqués par le iode 131 en scintigraphic pulmonaire. L’influence des lavages successifs, le temps de conservation, la stérilisation additionnelle et la qualité initiale du sérum albumine humain sur la pureté radiochimique et les tests biologiques de ce produit ont été étudiés.

Es wurden jene Kriterien festgelegt, die notwendig sind, um die Brauchbarkeit von ¹³¹J-Albuminmakroaggregaten zur Lungenszintigraphie zu bestimmen. Die Einflüsse zusätzlicher Waschungen, Lagerungszeit, zusätzlicher Sterilisation und der Qualität des Human-Serumalbumins als Ausgangsmaterial auf die radiochemische Reinheit und auf das biologische Verhalten des Präparates wurden untersucht.

Full Text

References

References
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