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Nuklearmedizin 1969; 08(04): 339-348
DOI: 10.1055/s-0038-1624683
Originalarbeiten — Original Articles — Travaux Originaux
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Treatment of the Autonomous „Hot“ Nodule of the Thyroid with 131I

Behandlung von autonomen „heißen“ Knoten der Schilddrüse mit 131JTraitement de nodules autonomes „chauds“ de la thyroïde au 131I
René. Cárdenas
1   From the Department of Nuclear Medicine (Director: Dr. R. Cárdenas) of the Oncological and Radiobiological Institute (Director: Prof. Dr. 2. Marinello) Habana, Cuba
,
Juan. Oliva
1   From the Department of Nuclear Medicine (Director: Dr. R. Cárdenas) of the Oncological and Radiobiological Institute (Director: Prof. Dr. 2. Marinello) Habana, Cuba
› Author Affiliations
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Publication History

Received: 15 August 1969

Publication Date:
23 January 2018 (online)

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Summary

Thirty-four women with single autonomous “hot” nodules of the thyroid were treated with 131I. There was a variable degree of thyrotoxicosis in 26 cases while in 3 others there was only local cervical discomfort. The total amount administered varied between 2 and 80 mCi of 131I and the radiation dose to the thyroid from 2 to 450 krads. The nodule and symptoms disappeared in 14 of the patients, while in the other 14 the lesion decreased in size and the clinical manifestations improved. Only in six patients was the result unsatisfactory, without change in the size of the nodule. Results are analysed on the basis of the quantity of radioiodine administered.

Modifications of the scintigram before and after treatment are discussed, observing that the “cooling” of the nodule and the reappearance of the surrounding gland are signs of good prognosis.

A case is described in which the therapy failed and a thyroid carcinoma was found after surgical resection. Two cases of the series in which there were slight transitory manifestations of post-therapeutic hypothyroidism are also reported.

Es wird über 34 Patientinnen mit hyperfunktionierenden autonomen Schilddrüsenknoten (solitären heißen Knoten) berichtet, die mit 131J behandelt wurden.

Die Totalmenge betrug zwischen 2 und 80 mCi 131J, und die Strahlendosis zwischen 2 und 450 krads.

Es werden die verschiedenen Formen der Szintigraphie vor und nach der Behandlung diskutiert.

Die Autoren berichten über einen Fall , in dem die Therapie erfolglos blieb und bei der Operation ein Schilddrüsenkarzinom entdeckt wurde.

Am Ende wird von 2 Fällen berichtet, die nach der 131J-Behandlung eine vorübergehende Hypofunktion der Schilddrüse zeigten.

34 femmes affectées d’un nodule solitaire „chaud“ autonome de la thyroïde ont été traités au 131I. 26 cas étaient atteints de thyrotoxicose à différents degrés, les 3 autres seulement de malaises cervicaux localisés. La quantité de 131I administrée variait entre 2 et 80 mCi et la dose d’irradiation de la thyroïde entre 2 et 450 krads. Dans 14 des cas le nodule et les symptômes ont disparu, dans les 14 autres la lésion a diminué ainsi que les symptômes cliniques. Dans 6 cas seulement les résultats ont été insatisfaisants, le nodule n’ayant pas diminué de taille. Les résultats ont été analysés sur la base de la quantité de radioiode administrée. Des modifications du scintigramme avant et après le traitement ont été analysées et on a observé que le „refroidissement“ du nodule et la réapparition de la glande sont signes d’un bon prognostic. Il est décrit un cas où le thérapeutique n’a pas eu d’effet et où l’on a découvert un carcinome lors de l’intervention chirurgicale. Deux cas sont également cités où l’on a trouvé de faibles symptômes transitoires d’hypothyroïdisme post-thérapeutique.

 

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