Zur Neurobiologie der Insomnie

Kai Spiegelhalder

doi:10.1055/s-0038-1624643

Schlaf, Table of Contents

Schlaf 2016; 05(03): 108-111
DOI: 10.1055/s-0038-1624643

Review

Schattauer GmbH

Zur Neurobiologie der Insomnie

Kai Spiegelhalder

Abstract

Chronische Ein- und Durchschlafstörungen, die die Tagesbefindlichkeit beeinträchtigen, werden als Insomnie bezeichnet. Die Ursachen dieser Schlafstörung sind relativ schlecht verstanden, wobei die Forschung hierzu in den vergangenen Jahrzehnten primär psychologisch ausgerichtet war. Diesbezüglich hat jedoch in den letzten Jahren ein Umdenken stattgefunden. Seitdem werden vermehrt neurobiologische Methoden eingesetzt, um zu einem besseren Verständnis der Entstehung der Insomnie zu gelangen. Diesbezügliche Arbeiten werden in diesem Artikel überblicksartig zusammengefasst. Die Hoffnung der in diesem sich rasch entwickelnden Forschungsfeld arbeitenden Wissenschaftler ist, dass ein Verständnis der neurobiologischen Mechanismen, die zu Ein- und Durchschlafstörungen führen, zu einer Verbesserung der Behandlung der chronischen Insomnie beitragen kann.

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References

Literatur
1 Morin CM, Drake CL, Harvey AG. et al. Insomnia disorder. Nat Rev Dis Primers 2015; 1: 15026.
2 Thiart H, Ebert DD, Lehr D. et al. Internet-based cognitive behavioral therapy for insomnia: a health economic evaluation. Sleep, im Druck.
3 Qaseem A, Kansagara D, Forciea MA, Cooke M, Denberg TD. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med, im Druck.
4 Morin CM, Gaulier B, Barry T, Kowatch RA. Patients' acceptance of psychological and pharmacological therapies for insomnia. Sleep 1992; 15: 302-305.
5 Trauer JM, Qian MY, Doyle JS. et al. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Ann Intern Med 2015; 163: 191-204.
6 Wu JW, Appleman ER, Salazar RD, Ong JC. Cognitive behavioral therapy for insomnia comorbid with psychiatric and medical conditions: a meta-analysis. JAMA Intern Med 2015; 175: 1461-1472.
7 Spielman AJ, Caruso LS, Glovinsky PB. A behavioral perspective on insomnia treatment. Psychiatr Clin North Am 1987; 10: 541-533.
8 Morin CM, Vallières A, Ivers H. Dysfunctional beliefs and attitudes about sleep (DBAS): validation of a brief version (DBAS-16). Sleep 2007; 30: 1547-1554.
9 Espie CA, Broomfield NM, MacMahon KM, Macphee LM, Taylor LM. The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review. Sleep Med Rev 2006; 10: 215-245.
10 Riemann D, Nissen C, Palagini L. et al. The neurobiology, investigation, and treatment of chronic insomnia. Lancet Neurol 2015; 14: 547-558.
11 Wing YK, Zhang J, Lam SP, Li SX, Tang NL, Lai KY, Li AM. Familial aggregation and heritability of insomnia in a community-based study. Sleep Med 2012; 13: 985-990.
12 Hublin C, Partinen M, Koskenvuo M, Kaprio J. Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort. Sleep 2011; 34: 957-964.
13 Watson NF, Goldberg J, Arguelles L, Buchwald D. Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins. Sleep 2006; 29: 645-649.
14 Byrne EM, Gehrman PR, Medland SE. et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet 2013; 162B: 439-451
15 Ban HJ, Kim SC, Seo J, Kang HB, Choi JK. Genetic and metabolic characterization of insomnia. PLoS One 2011; 6: e18455.
16 Zhang J, Lam SP, Li SX. et al. A community-based study on the association between insomnia and hypothalamic-pituitary-adrenal axis: sex and pubertal influences. J Clin Endocrinol Metab 2014; 99: 2277-2287.
17 Yang AC, Tsai SJ, Yang CH, Kuo CH, Chen TJ, Hong CJ. Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. J Affect Disord 2011; 131: 179-185.
18 Spiegelhalder K, Fuchs L, Ladwig J. et al. Heart rate and heart rate variability in subjectively reported insomnia. J Sleep Res 2011; 20: 137-145.
19 Israel B, Buysse DJ, Krafty RT. et al. Short-term stability of sleep and heart rate variability in good sleepers and patients with insomnia: for some measures, one night is enough. Sleep 2012; 35: 1285-1291.
20 Perlis ML, Smith MT, Andrews PJ, Orff H, Giles DE. Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. Sleep 2001; 24: 110-117.
21 Winkler A, Auer C, Doering BK, Rief W. Drug treatment of primary insomnia: a meta-analysis of polysomnographic randomized controlled trials. CNS Drugs 2014; 28: 799-816.
22 Meyerhoff DJ, Mon A, Metzler T, Neylan TC. Cortical GABA and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. Sleep 2014; 37: 893-900.
23 Plante DT, Jensen JE, Schoerning L, Winkelman JW. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?. Neuropsychopharmacology 2012; 37: 1548-1557.
24 Winkelman JW, Buxton OM, Jensen JE. et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS).
25 Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine GW, Sanacora G. Cortical GABA levels in primary insomnia. Sleep 2012; 35: 807-814.
26 Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ. Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry 2004; 161: 2126-2128.
27 Drummond SP, Walker M, Almklov E. et al. Neural correlates of working memory performance in primary insomnia. Sleep 2013; 36: 1307-1316.
28 Altena E, van der Werf YD, Sanz-Arigita EJ, Voorn TA, Rombouts SA, Kuijer JP, van Someren EJ. Prefrontal hypoactivation and recovery in insomnia. Sleep 2008; 31: 1271-1276.
29 Baglioni C, Spiegelhalder K, Regen W. et al. Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli. Sleep 2014; 37: 1907-1917.
30 Altena E, Vrenken H, van der Werf YD, van den Heuvel OA, van Someren EJ. Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry 2010; 67: 182-185.
31 Riemann D, Voderholzer U, Spiegelhalder K, Hornyak M, Buysse DJ, Nissen C, Hennig J, Perlis ML, van Elst LT, Feige B. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep 2007; 30: 955-958.
32 Spiegelhalder K, Regen W, Baglioni C, Klöppel S, Abdulkadir A, Hennig J, Nissen C, Riemann D, Feige B. Insomnia does not appear to be associated with substantial structural brain changes. Sleep 2013; 36: 731-737.
33 Saebipour MR, Joghataei MT, Yoonessi A, Sadeghniiat-Haghighi K, Khalighinejad N, Khademi S. Slow oscillating transcranial direct current stimulation during sleep has a sleep-stabilizing effect in chronic insomnia: a pilot study. J Sleep Res 2015; 24: 518-525.
34 Frase L, Piosczyk H, Zittel S. et al. Modulation of Total Sleep Time by Transcranial Direct Current Stimulation (tDCS). Neuropsychopharmacology, im Druck.
35 Sulzer J, Haller S, Scharnowski F. et al. Real-time fMRI neurofeedback: progress and challenges. Neuroimage 2013; 76: 386-399.