On the Theory of the Measurement of the First-Pass Pulmonary Extraction Using the Indicator Dilution Technique

Theory and concept of extraction involving invasive as well as non-invasive procedures to assess the first-pass extraction of tracers based on the indicator dilution technique are discussed. The experimental result of a noninvasive method using a gamma scintillation camera-computer system of firstpass pulmonary extraction of N-lsopropyl-¹²³l-p-lodoamphetamine (¹²³I-IMP) are also discussed.

Zusammenfassung

Theorie und Konzept der Bestimmung der first-pass Extraktion auf der Basis der Indikatorverdünnungsmethode werden sowohl für invasive als auch für nichtinvasive Verfahren diskutiert. Die First-pass Lungenextraktion von N-Isopropyl-¹²³J-p-Jodamphetamin (¹²³J-IMP) wird anhand experimenteller Daten mit einer Gammakamera und Rechner besprochen.

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