Nuklearmedizin 1986; 25(02): 45-49
DOI: 10.1055/s-0038-1624318
Originalarbeiten - Original Articles
Schattauer GmbH

Retention and Subcellular Distribution of 67Ga in Normal Organs

Retention und subzelluläre Verteilung von 67Ga in normalen Organen
A. Ando
1   From the School of Allied Medical Professions, Tokyo, Japan
,
I. Ando
1   From the School of Allied Medical Professions, Tokyo, Japan
,
T. Hiraki
1   From the School of Allied Medical Professions, Tokyo, Japan
,
K. Hisada
2   From the School of Medicine, Tokyo, Japan
,
K. Nitta
3   Kanazawa University, Kanazawa, and Daiichi Radioisotope Laboratories Ltd, Tokyo, Japan
,
H. Ogawa
3   Kanazawa University, Kanazawa, and Daiichi Radioisotope Laboratories Ltd, Tokyo, Japan
› Institutsangaben
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Publikationsverlauf

Received: 20. August 1985

Publikationsdatum:
12. Januar 2018 (online)

Using normal rats, retention values and subcellular distribution of 67Ga in each organ were investigated. At 10 min after administration of 67Ga-citrate the retention value of 67Ga in blood was 6.77% dose/g, and this value decreased with time. The values for skeletal muscle, lung, pancreas, adrenal, heart muscle, brain, small intestine, large intestine and spinal cord were the highest at 10 min after administration, and they decreased with time. Conversely, this value in bone increased until 10 days after injection. But in the liver, kidney, and stomach, these values increased with time after administration and were highest 24 h or 48 h after injection. After that, they decreased with time. The value in spleen reached a plateau 48 h after administration, and hardly varied for 10 days. From the results of subcellular fractionation, it was deduced that lysosome plays quite an important role in the concentration of 67Ga in small intestine, stomach, lung, kidney and pancreas; a lesser role in its concentration in heart muscle, and hardly any role in the 67Ga accumulation in skeletal muscle. In spleen, the contents in nuclear, mitochondrial, microsomal, and supernatant fractions all contributed to the accumulation of 67Ga.

Zusammenfassung

Bei normalen Ratten wurden die Retentionswerte und die subzelluläre Verteilung von 6 7Ga in jedem Organ untersucht. 10 min nach Verabreichung von 6 7Ga-Zitrat lag der Retentionswert von 6 7Ga im Blut bei 6.77% Dosis/g; dieser Wert nahm allmählich ab. Dies Retentionswerte für Skelettmuskel, Lunge, Pankreas, Nebenniere, Herzmuskel, Gehirn, Dünndarm, Dickdarm und Rückenmark waren 10 min nach Verabreichung am höchsten und nahmen mit der Zeit ab. Innerhalb von 10 Tagen nahm dagegen der Wert im Knochen nach Injektion zu. In Leber, Niere und Magen steigerten sich diese Werte und waren nach 24 oder 48 h am höchsten; danach nahmen sie langsam ab. Der Wert in der Milz erreichte das Plateau 48 h nach Verabreichung und veränderte sich innerhalb von 10 Tagen subzellulären Separation besagen, daß Lysosome für die Konzentration von 6 7Ga bei Dünndarm, Magen und Pankreas eine wichtige Rolle spielten, dagegen eine geringere im Herzmuskel, und fast keine im Skelettmuskel. Bei der Milz waren alle Fraktionsinhalte von Kernen, Mitochondrien und Zytoplasmen an der Akkumulation von 6 7Ga beteiligt.

 
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