Recent Developments in the Field of 123I-Radiopharmaceuticals

H.-J. Machulla; E. J. Knust

doi:10.1055/s-0038-1624203

Nuklearmedizin - NuclearMedicine, Inhaltsverzeichnis

Nuklearmedizin 1984; 23(03): 111-118
DOI: 10.1055/s-0038-1624203

Originalarbeiten – Original Articles

Schattauer GmbH

Recent Developments in the Field of ¹²³I-Radiopharmaceuticals ^[*]

Neuere Entwicklungen auf dem Gebiet der ¹²³J-markierten Radiopharmazeutika

H.-J. Machulla

¹From the Institut für Medizinische Strahlenphysik und Strahlenbiologie, Universitätsklinikum Essen, Essen, Federal Republic of Germany

,

E. J. Knust

¹From the Institut für Medizinische Strahlenphysik und Strahlenbiologie, Universitätsklinikum Essen, Essen, Federal Republic of Germany

› Institutsangaben

Abstract

Summary

Due to its advantageous nuclear physical properties iodine-123 is an excellent label for radiopharmaceuticals very well suited for measurements by γ-cameras and single-photon emission tomography. The development of ¹²³I-radiopharmaceuticals should be based on a clear biochemical concept, reliable labelling procedures and careful pharmacokinetic studies in order to evaluate the physiological behaviour of the radioiodinated compounds being analogues of metabolic substrates. The development of ¹²³I-labelled fatty acids and biogenic amines clearly proved the successful use of ¹²³I for labelling compounds applied in medical diagnosis.

Zusammenfassung

Aufgrund seiner hervorragenden kernphysikalischen Eigenschaften stellt ¹²³J ein ausgezeichnetes Radionuklid zur Markierung von Radiopharmaka dar, die somit sehr gut geeignet sind für Messungen mit herkömmlichen γ-Kameras oder mittels der Single Photon Emission Tomography (SPECT). Voraussetzung für die Entwicklung von ¹²³J-Radiopharmaka sind klare biochemische Konzepte, zuverlässige Markierungsmethoden und pharmakokinetische Studien zur Ermittlung des physiologischen Verhaltens radiojodierter Verbindungen als Analoga metabolischer Substrate. Die Entwicklung ¹²³J-markierter Fettsäuren und biogener Amine beweist sehr deutlich die erfolgreiche Verwendungsmöglichkeit von ¹²³J zur Markierung von Verbindungen für die Anwendung in der nuklear-medizinischen Diagnose.

Volltext

Referenzen

References
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Recent Developments in the Field of 123I-Radiopharmaceuticals [*]

Recent Developments in the Field of ¹²³I-Radiopharmaceuticals ^[*]