Red Blood Cell Labelling by Intravenous Injection Of ^99mTC-PAEP^[*]

Summary

In vivo red blood cell (RBC) labelling after the intravenous administration of PAEP (N-phosphorylaminoethyl-phosphate) and the subsequent injection of sodium pertechnetate 24 hrs later was studied. The results in rats were found to be similar to those obtained after i.v. administration of ^99mTc-PYP, a radiopharmaceutical routinely used for in vivo RBC labelling.

Zusammenfassung

Die In-vivo-Markierung roter Blutkörperchen wurde nach intravenöser Verabreichung von PAEP (N-Phosphorylamino-aethylphosphat) und einer nachfolgenden Injektion von Natriumpertechnetat 24 Std. später untersucht. Die Ergebnisse bei Ratten waren ähnlich jenen nach i.v. Verabreichung von ^99mTc-PYP, eines Radiopharmakons, das routinemäßig zur In-vivo-Markierung von Erythrozyten verwendet wird.

^* 3rd International Symposium on Radiopharmacology, Freiburg i. Br., September 1983.

• References

• 1 Bardy A, Fouye H, Gobin R, Beydon J, de Tovar Panneciere C, Hegesippe M. Technetium-99m labelling by means of stannous pyrophosphate: Application to Bleomycin and red blood cells. J. nucl. Med 16: 435 1975;
• 2 Chiotellis E, Varvarigou A, Vavouraki H, Smirniotis B, Stavraka A, Papadimitriou J. ^99mTc-labelled N-phosphorylaminoethyl-phosphate (^WmTc-PAEP) as bone and myocardial infarcted agent. Studies in experimental animals. Proc., Third World Congr. Nucl. Med. and Biol.. 1982
• 3 Chiotellis E, Varvarigou A, Smirniotis B, Papadimitriou J. Evaluation of ^99mTcN phosphorylaminoethyl-phosphate (^99mTc-PAEP) as imaging agent in acute myocardial infarction (under publication).
• 4 Echelman W, Richards P, Hauser W, Aitkins W. Technetium-labeled red blood cells. J. nucl. Med 12: 22 1971;
• 5 McRae J, Sugar RM, Shipley B, Hook GR. Alterations in tissue distribution of ^99mTc-pertechnetate in rats given stannous tin. J. nucl. Med 15: 151 1974;
• 6 Stokely EN, Parkey RW, Bonte FJ, Graham KD, Marvin RT. Gated blood pool imaging following ^99mTc-stannous pyrophosphate imaging. Radiology 120: 433 1976;
• 7 Weinstein MB, Snoak WM. Technical difficulties in ^99mTc-labelling of erythrocytes. J. nucl. Med 11: 41 1971;
• 8 Yano Y, McRae J, Van Dyke DC, Anger GO. ^99mTc-Sn-EHDP for bone scanning. J. nucl. Med 14: 13 1973;