Non-Specific Tumor-Seeking Radiopharmaceuticals–Report and Future Aspects^[*]

Summary

A review is made of some currently held views regarding the mechanism of uptake of non-specific tumor-seeking labelled compounds, with special reference to the role of cell membranes and the transfer mechanisms across such membranes. Results with various radiopharmaceuticals used in tumor scintigraphy are discussed and some suggestions are made for possibly profitable research to be done in that area.

Zusammenfassung

Es wird eine Übersicht über einige derzeit gängige Ansichten bezüglich der Mechanismen der Tumorspeicherung unspezifischer markierter Verbindungen mit besonderer Berücksichtigung der Rolle der Zellmembranen und der Transfervorgänge durch solche Membranen gegeben. Die Ergebnisse mit verschiedenen, in der Tumorszintigraphie verwendeten Radiopharmaka werden diskutiert und einige Vorschläge für möglicherweise gewinnbringende Studien auf diesem Gebiet gemacht.

^* 3rd International Symposium on Radiopharmacology, Freiburg i. Br., September 1983.

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