IgG-Myelom mit Lambda-Leichtketten-Restriktion bei einem Kater

Zusammenfassung

Bei einer wegen Apathie, Kachexie und intermittierenden Erbrechens in der Klinik vorgestellten männlichen Europäischen Kurzhaarkatze wurde ein multiples Myelom diagnostiziert. Die Röntgenaufnahmen zeigten multiple lytische Knochenläsionen im Bereich der Wirbelsäule, der Rippen, des Beckens sowie dem Skelett der Ober- und Unterschenkel. Die Blutuntersuchung ergab eine Hypergammaglobulinämie, eine Hyperkalzämie, eine Azotämie sowie eine regenerative hämolytische Anämie. Die Serumelektrophorese sowie eine histopathologische Untersuchung des Knochenmarks bestätigten die Diagnose. In der immunhistochemischen Untersuchung reagierten die Tumorzellen mit Antikörpern gegen IgG und gegen Lambda-Leichtketten.

Summary

A multiple myeloma was diagnosed in a male European Shorthair cat with apathia, kachexia and intermittent vomiting. Radiographic examination revealed multiple lytic bone lesions in the vertebral column, ribs, pelvis, as well as in the femur, tibia and fibula on both sides. Routine blood examination showed hyperglobulinaemia, hypercalcaemia, azotaemia and regenerative haemolytic anaemia. The diagnosis was confirmed by serum electrophoresis and histopathologic examination of bone marrow. Evaluation of immunostaining of neoplastic cells revealed positive labelling by antibodies against immunoglobulin G and lambda-type light chain.

Schlüsselwörter

multiples Myelom - Katze - Hyperkalzämie - lytische Knochenläsionen - Leichtkettenrestriktion

Key words

Multiple myeloma - Cat - Hypercalcaemia - Lytic bone lesions - Light-chain restriction

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