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Nuklearmedizin 1961; 01(01): 54-58
DOI: 10.1055/s-0037-1621134
Originalarbeiten — Original Articles — Travaux Originaux
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An Autoradiographic Study of the Incorporation of S35 in the Urinary Bladder of the Female Mouse Following Administration of Radiosulphate

Sven Englund
1   From the Isotope Laboratory, Department of Obstetrics and Gynecology (Head: Prof. P. Wetterdal). Sabbatsberg Sjukhus, Karolinska Institutet, Stockholm, Sweden
,
Björn Westin
1   From the Isotope Laboratory, Department of Obstetrics and Gynecology (Head: Prof. P. Wetterdal). Sabbatsberg Sjukhus, Karolinska Institutet, Stockholm, Sweden
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Publication History

Publication Date:
03 February 2018 (online)

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Summary

An autoradiographic study of the urinary bladder of the mouse with ligated ureters following subcutaneous administration of radiosulphate showed a slight S35 uptake in bladder epithelium, a high uptake in the subepithelial tissue of the mucosa and a slight to moderate uptake in the bladder wall. The absorption through the bladder mucosa in animals with intact ureters was negligible. Oestrogen and progesterone did not influence the uptake of S35 in spayed mice.

Résumé

La fixation de S35 après administration souscutanée en forme de radiosulfate dans la vessie urinaire de souris aux urétères liés montre une concentration faible dans l’épithèle de la vessie, grande dans le tissu sousépithélial de la muqueuse et faible à modérie dans la paroi de la vessie. L’absorption à travers la muqueuse de la vessie des animaux avec des urétères intacts était negligible. Oestrogène et Progesterone n’avaient pas d’influence sur la fixation de S35 dans les souris examinés.

Zusammenfassung

Die Aufnahme von S35 in die Harnblase der Maus nach subkutaner Gabe von Radiosulfat bei unterbundenen Ureteren zeigte eine geringe Konzentration im Blasenepithel, eine hohe im subepithelialen Gewebe der Schleimhaut und eine geringe bis mittlere in der Blasenwand. Die Absorption durch die Blasenschleimhaut bei Tieren mit intakten Ureteren war vernachlässigbar. Oestrogen und Progesteron beeinflußten die Aufnahme von S33 bei den untersuchten Mäusen nicht.

 

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