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Nuklearmedizin 1980; 19(01): 33-36
DOI: 10.1055/s-0037-1620929
Originalarbeiten - Original Articles
Schattauer GmbH

The Possibilities of Scintigraphic Visualization of Surfactants in the Lung of the Rat

Möglichkeiten der szintigraphischen Darstellung der oberflächenaktiven Rattenlunge
E. Koren
1   From the “Dr. M. Stojanovic” Clinical Hospital, Clinic of Nuclear Medicine and Oncology, Zagreb, Yugoslavia
,
K. Filjak
1   From the “Dr. M. Stojanovic” Clinical Hospital, Clinic of Nuclear Medicine and Oncology, Zagreb, Yugoslavia
,
A. Gadže
1   From the “Dr. M. Stojanovic” Clinical Hospital, Clinic of Nuclear Medicine and Oncology, Zagreb, Yugoslavia
,
Š. Spaventi
1   From the “Dr. M. Stojanovic” Clinical Hospital, Clinic of Nuclear Medicine and Oncology, Zagreb, Yugoslavia
› Author Affiliations
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Received: 10 October 1979

Publication Date:
09 January 2018 (online)

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Incorporation of radioactive iodine into the surfactant system of the rat lung has been studied. Specially prepared particles labelled by 125I-oleic acid or 131I-oleic acid were injected intravenously and the distribution of radioiodine in the body of the animals was observed at various time intervals by means of a gamma camera and a gamma counter. The results showing appreciable accumulation of isotope in the lungs and the surfactant phospholipids, constitute a basis for the development of a new scintigraphic method for studying metabolic functions and morphology of the lung.

Die Einlagerung von radioaktiv markiertem Jod in das oberflächenaktive Lungengewebe der Ratte wurde untersucht. Speziell präparierte Partikel, die mit l25J-Ölsäure oder 131J-Ölsäure markiert waren, wurden i.v. appliziert und die Verteilung des Radiojods in den Tieren mit Hilfe einer Gamma-Kamera und eines Gamma-Counters zu verschiedenen Zeiten festgestellt. Die Ergebnisse zeigen eine nennenswerte Anreicherung in den Lungen und den oberflächenaktiven Phospholipiden und ergeben so eine Basis für die Entwicklung neuer szintigraphischer Untersuchungen zur Bestimmung morphologischer und metabolischer Daten der Lunge.

 

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