99mTc-Unithiol-Komplex, ein neues Radiopharmazeutikum für die Nierenszintigraphie.

L. Darte; M. Oginski; R. B. R. Persson

doi:10.1055/s-0037-1620871

Nuklearmedizin - NuclearMedicine, Inhaltsverzeichnis

Nuklearmedizin 1979; 18(01): 26-35
DOI: 10.1055/s-0037-1620871

Originalarbeiten - Original Articles

Schattauer GmbH

^99mTc-Unithiol Complex, a New Radiopharmaceutical for Kidney Scintigraphy

III. Studies of Labelling Unithiol with ^99mTc ^99mTc-Unithiol-Komplex, ein neues Radiopharmazeutikum für die Nierenszintigraphie.III. Untersuchungen über die Markierung von Unithiol mit ^99mTc

L. Darte

¹ From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden

,

M. Oginski

¹ From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden

,

R. B. R. Persson

¹ From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden

› Institutsangaben

Abstract

Labelling of 2, 3-dimercaptopropane sodiumsulphonate (Unithiol) with 99mTc resulted in essentially three components in the GCS pofile: the top zone, a low-molecular Complex A and a high-molecular Complex B. In the presence of tin metal a fourth component, Complex C, could be distinguished. Complex A was relatively independent of pH, the proportion of Complex B increased with increasing pH. Methods were developed for preparing, with over 80% labelling efficiency, either Complex A or Complex B, each having high stability in the preparation vials and in human blood.

Die Markierung von 2,3-dimercaptopropannatriumsulfonat (Unithiol) mit 99mTc ergab im Wesentlichen drei Komponenten im Gel-Säulenchromatogramm: die oberste Zone, einen niedermolekularen Komplex A und einen hochmolekularen Komplex B. In Gegenwart von metallischem Zinn konnte eine vierte Komponente, Komplex C, erkannt werden. Der Komplex A war vom pH-Wert relativ unabhängig, während der Anteil an Komplex B mit steigendem pH größer wurde. Es wurden Methoden der Herstellung - mit 80 %iger Markierungseffizienz - von entweder Komplex A oder Komplex B entwickelt, wobei das jeweilige Produkt sowohl in der Eprouvette als auch in menschlichem Blut sehr stabil war.

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Referenzen

References
(1) Oginski M, Rembelska M. 99mTc-Unithiol complex, a new pharmaceutical for kidney scintigraphy. Nucl. Med XV: 282-286 1976; .
(2) Liniecki J, Surma M, Mlodkowska E, Oginski M. 99mTc-Unithiol complex, a new pharmaceutical for kidney scintigraphy. II. Comparison of renal scintigrams in man, obtained by means of 197Hg-chlormerodrin or 99mTc-Unithiol complex. Nucl.-Med XVI: 179-182 1977; .
(3) Arnold RW, Subramanian G, McAfee JG, Blair RJ, Thomas FD. Comparison of 99mTc complexes for renal imaging. J. Nucl. Med 16: 357-367 1975; .
(4) Asbel S. Quecksilbervergiftungen durch organische Gifte. Medicina, Moscow 1964.
(5) Persson RBR, Strand SE. Labelling processes and short-term biodynamical behaviour of different types of
(6) Persson RBR, Darte L. Gel chromatography column scanning for the analysis of 99mTc-labelled compounds. J. Chrom 101: 315-326 1974; .
(7) Persson RBR. Gel chromatography column scanning (GCS). A method for identification and quality control of 99mTc-radiopharmaceuticals. In: Radiopharmaceuticals. Soc. Nucl. Med., N. Y. (USA), 1975, p. 228.
(8) Darte L, Persson RBR, Söderbom L. Quality control and testing of 99mTc-MAA. Nucl.-Med XV: 80-85 1976; .
(9) Persson RBR, Darte L. Recent developments of the gel chromatography column scanning method. A rapid analytical tool in radiopharmaceutical chemistry. In: First International Symposium on Radiopharmaceutical Chemistry NY (USA), 1976. J. Labelled Compounds and Radiopharmaceuticals 13. 165 1977 .
(10) Persson RBR, Darte L. Labelling plasmin with 99mTc for scintigraphic localization of thrombi. Int. J. appl. Radiat 28: 97 1977; .
(11) Darte L, Persson RBR. Some aspects on quality control and stability tests of 99mTc-pyrophosphate for imaging myocardial infarcts. NUC-Compact 4: 120-123 1977; .
(12) Oginski M, Strand SE, Darte L, Persson RBR. Comparative bio-kinetic and in vivo distribution studies with various 99mTc-Unithiol preparations and other kidney agents. To be published. 99mTc-labelled complexes. In: Radiopharmaceuticals and Labelled Compounds, Vol. I. IAEA, Vienna, 1973, p. 169.