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Nuklearmedizin 1981; 20(02): 90-93
DOI: 10.1055/s-0037-1620723
Originalarbeiten – Original Articles
Schattauer GmbH

Hepatobiliary Kinetics of 113mIn-Phenolphthalexon

Leber- und Gallenkinetik des 113mIn-Phenolphthalexon
M. C. Patel
1   From the Radiation Medicine Centre, Medical Group, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay, India
,
P.B. Parab
1   From the Radiation Medicine Centre, Medical Group, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay, India
,
U.R. Raikar
1   From the Radiation Medicine Centre, Medical Group, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay, India
,
R.D. Ganatra
1   From the Radiation Medicine Centre, Medical Group, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay, India
› Author Affiliations
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Publication History

Received: 21 March 1978

Publication Date:
10 January 2018 (online)

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Phenolphthalexon, a compound with iminodiacetic acid as a functional group, has been labelled with 113mIn to high chemical purity and its usefulness in studies of biliary excretion patency has been studied. Organ distribution of 113mIn-phenolphthalexon in mice was characterized by high liver uptake (50.8% of the administered dose after 5 min) and rapid clearance through the gall bladder. An animal model for studying obstruction of biliary excretion has been developed. Data on the kinetics of the radiopharmaceutical were obtained by collecting in-vivo data through an on-line computer.

Phenolphthalexon, eine Verbindung mit Iminodiessigsäure als Funktionsgruppe, wurde mit 113mIn mit großer chemischer Reinheit markiert und seine Verwendungsfähigkeit zur Untersuchung der Durchgängigkeit der Gallenwege geprüft. Die Verteilung von 113mIn-Phenolphthalexon war bei Mäusen durch eine hohe Leberspeicherung (50,8% der verabreichten Dosis nach 5 min) und durch eine rasche Clearance durch die Gallenblase charakterisiert. Es wurde ein Modell für Untersuchungen der Verlegung der Gallenwege beim Tier entwickelt. Daten über die Kinetik des Radio-pharmakons wurden mittels Speicherung der in-vivo Ergebnisse in einem on-line Computer erhalten.

 

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