Nuklearmedizin 1981; 20(06): 265-267
DOI: 10.1055/s-0037-1620655
Originalarbeiten – Original Articles
Schattauer GmbH

Scintigraphic Myocardial Imaging with 99mTc-Labelled Pyrophosphate of Experimentally Produced Cardiomyopathy in Dogs

Myokardszintigraphie mit 99mTc-markiertem Pyrophosphat bei experimentell produzierten Kardiomyopathien bei Hunden
F. Duška
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
J. Novák
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
J. Vižďa
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
J. Kubíček
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
P. Kafka
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
Y. Mazurová
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
,
P. Bradna
1   From the Department of Normal and Pathological Physiology and the Division of Nuclear Medicine, Dept. of Radiology, Charles University Faculty of Medicine, Hradec Králové, Czechoslovakia
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Publikationsverlauf

Received:03. April 1981

Publikationsdatum:
09. Januar 2018 (online)

Scintigraphic examination of the myocardium using 99mTc-labelled pyrophosphate was carried out in 10 dogs with experimentally produced cardiomyopathy. This was brought about by intravenous administration of high doses of adrenalin and theophylline. The scan was positive in 8 out of 10 dogs. "Hot" foci were very extensive. The degree of accumulation was however low (2+). Histological examination of the myocardium using the light microscope showed only scarcely distinguishable damage to the tissue without the presence of necrosis. ECG examinations were normal in all cases. By means of 99mTc-labelled pyrophosphate even very small myocardial disorders can thus be detected. This fact may be of clinical importance for an early diagnosis of heart lesions.

Es wurde eine szintigraphische Myokard-Untersuchung mittels 99mTc-markierten Pyrophosphats bei 10 Hunden mit einer experimentell verursachten Kardiomyopathie durchgeführt. Diese war durch intravenöse Verabreichung hoher Adrenalin- und Theophyllindosen herbeigeführt worden. Der Myokard-Scan war positiv bei 8 von 10 Hunden. „Heiße” Herde waren sehr ausgedehnt, die Speicherung war jedoch niedrig (2+). Die histologische Myokard-Untersuchung mittels des Lichtmikroskops ergab einen kaum feststellbaren Gewebsschaden ohne Vorhandensein einer Nekrose. Die EKG-Untersuchungen waren in allen Fällen normal. Mittels 99mTc-markierten Pyrophosphats können daher auch sehr geringfügige Myokardstörungen entdeckt werden. Diese Tatsache kann für eine Frühdiagnose der Herzschäden von klinischer Bedeutung sein.

 
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